Journal
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
Volume 34, Issue -, Pages 33-42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejpn.2021.07.008
Keywords
Visual evoked potential; VEP; Giant amplitude; Raised intracranial pressure; rICP; Craniosynostosis; Intracranial hypertension
Categories
Funding
- NIHR Great Ormond Street Hospital Biomedical Research Centre
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The study analyzed giant amplitude pattern reversal VEPs in 2750 children aged 16 years and under, revealing associations between this phenomenon and a risk of raised intracranial pressure, with conditions such as craniosynostosis and idiopathic intracranial hypertension commonly identified. Structural associations included optic disc measurements and neuro-radiological findings, while raised ICP was confirmed in some cases through gold standard measurements.
Our aim is to elaborate the clinical significance of giant amplitude pattern reversal visual evoked po-tentials (VEPs) in children. 'Giant' amplitude VEPs exceed the upper 97.5th centile, 90% CI for age. We scrutinised 2750 pattern VEPs recorded to international standards between Jan 2015 and 2017 from children aged 16 years and under, attending a specialist children's hospital. Twenty seven children, median age 6yrs, (range 1-16 yrs), were identified with giant VEPs (P100 amplitude range 65-163 mV). Most, 22/27 (81%), had conditions associated with a risk of raised ICP. Sixteen of these twenty two children had craniosynostosis; six multi-sutural and eight single suture disease. Others had Idiopathic Intracranial Hypertension, arachnoid cyst, NF1 with shunted hydrocephalus, chronic infantile neuro-logical cutaneous and articular (CINCA) syndrome, nephrotic cystinosis and obstructive sleep apnoea. Five children presented with a range of conditions, some associated with seizures some symptomatic, but as yet undiagnosed. Frequent structural associations were optical coherence tomography measures of optic disc maximum anterior axial horizontal retinal thickness projection >160 mm and neuro-radiological findings of CSF effacement and copper beaten appearance. Ultrasonography measures of optic nerve sheath diameters varied, but in one child took 2 years to resolve after treatment for raised ICP. Optic disc gradings by fundoscopy were mostly normal, as were visual acuities. Raised ICP was confirmed by gold standard ICP bolt measurements in five of seven children tested. These data suggest that rICP should be considered if a child has sustained giant amplitude VEPs at normal latency. (C) 2021 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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