Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 32, Pages 4555-4558Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100772
Keywords
2-Aminobenzophenones; Azides; Decarboxylation; Hydrolysis; One-pot reaction
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The novel synthetic method described in this study utilizes various 2-alkynyl arylazides to efficiently produce products in moderate to good yields under mild reaction conditions.
We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.
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