Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 37, Pages 5238-5242Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202101001
Keywords
Alkynes; Borane; Density functional calculations; Hydroarylation; Phenols
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A new strategy has been developed for the synthesis of 1,1-diaryl and triarylsubstituted alkenes through B(C6F5)(3)-catalyzed hydroarylation of alkynes with phenols. The reactions exhibit excellent regioselectivity and good stereoselectivity, with computational and experimental studies suggesting an acid-catalyzed isomerization mechanism for the formation of Z-triaryl substituted alkenes from internal alkynes and phenols.
A new strategy for the synthesis of 1,1-diaryl and triarylsubstituted alkenes has been developed utilizing B(C6F5)(3)-catalyzed hydroarylation of alkynes with phenols. The method provides a direct route to ortho-alkenylated phenols with both terminal and internal alkynes. The reactions show excellent regioselectivity, and good stereoselectivity was observed for the hydroarylation of internal alkynes. Computational and experimental studies suggest that for the reaction of internal alkynes and phenols, an acid-catalyzed isomerization mechanism involving two tertiary carbonium ion intermediates is responsible for the formation of Z-triaryl substituted alkenes.
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