Mixed Multimetallic tris(2-pyridylmethyl)amine Based Complexes: Synthesis and Chiroptical Properties

Continuous intensification of reaction screening methodologies has required the development of novel high-throughput analytical technologies. This urge involves also chirality related fields where nowadays novel methods for reliable, fast and effective analysis are developed. Within this field, chiroptical spectroscopies have emerged as promising techniques, in particular when they are combined with stereodynamic probes for optical signal amplification. We report here the synthesis and characterisation of a series of molecular architectures based on a modified tris(2-pyridylmethyl)amine (TPMA) complex which are able to amplify the electronic CD signal of phenylalanine. The study reports the synthesis of six novel TPMA based supramolecular architectures characterised by the presence of two different metals within the same molecule. Besides the synthesis, the study highlights how mixing metals influences the chiroptical properties of the formed compounds.

Automated summary

The continuous improvement of reaction screening methodologies has led to the development of novel high-throughput analytical technologies. Chiroptical spectroscopies have emerged as promising techniques, especially when combined with stereodynamic probes for optical signal amplification. Mixing metals in the synthesis of novel supramolecular architectures based on TPMA can influence the chiroptical properties of the formed compounds.