4.5 Review

When NO. Is not Enough: Chemical Systems, Advances and Challenges in the Development of NO. and HNO Donors for Old and Current Medical Issues

Related references

Note: Only part of the references are listed.
Article Anesthesiology

Effects of inhaled nitric oxide in COVID-19-induced ARDS - Is it worthwhile?

Christopher Lotz et al.

Summary: Inhalation of NO significantly improved oxygenation in COVID-19 ARDS patients. Severe ARDS patients had higher partial pressures of oxygen and reduced pulmonary vascular resistance after receiving iNO. Significant changes in pulmonary shunting were not observed.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2021)

Review Biochemistry & Molecular Biology

COVID-19 vaccines: where we stand and challenges ahead

Guido Forni et al.

Summary: The development of vaccines has made significant progress, but still faces various challenges, including different target populations, immunological adaptability of vaccines, and production and distribution issues. To ensure equitable access, protection of diverse subjects, and immunity against viral variants, multiple vaccines may be needed in the long run.

CELL DEATH AND DIFFERENTIATION (2021)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Virology

Nitric oxide (NO) and nanoparticles - Potential small tools for the war against COVID-19 and other human coronavirus infections

Joana C. Pieretti et al.

Summary: Nitric oxide plays a key role in the immune system and has shown potential in treating human coronavirus infections, including COVID-19. Through inhalation and the use of NO donors combined with nanomaterials, sustained release of NO can be achieved, enhancing its benefits and minimizing side effects.

VIRUS RESEARCH (2021)

Review Emergency Medicine

Role of high-dose intravenous nitrates in hypertensive acute heart failure

Kellie Wang et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

Review Chemistry, Multidisciplinary

New Designs for Phototherapeutic Transition Metal Complexes

Cinzia Imberti et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Veterinary Sciences

Antihypertensive potential of cis-[Ru(bpy)2(ImN)(NO)]3+, a ruthenium-based nitric oxide donor

Paula Priscila Correia Costa et al.

RESEARCH IN VETERINARY SCIENCE (2020)

Article Chemistry, Inorganic & Nuclear

The Underlying Mechanism of HNO Production by the Myoglobin-Mediated Oxidation of Hydroxylamine

Lucia Alvarez et al.

INORGANIC CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Photoinduced NO and HNO Production from Mononuclear {FeNO}6 Complex Bearing a Pendant Thiol

Chuan-Kuei Chiang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Johannes Karges et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Biochemistry & Molecular Biology

Pentacyanoferrate(II) complex of pyridine-4-and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities

Edinilton Muniz Carvalho et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Potential therapeutic approaches for a sleeping pathogen: tuberculosis a case for bioinorganic chemistry

Eduardo H. S. Sousa et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2020)

Article Chemistry, Physical

Two-Photon-Triggered NO Release via a Ruthenium-Nitrosyl Complex with a Star-Shaped Architecture

Margarita Romero Avila et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2020)

Article Biochemistry & Molecular Biology

A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity

Edinilton Muniz Carvalho et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro

Dario Akaberi et al.

REDOX BIOLOGY (2020)

Review Medicine, Research & Experimental

Review of clinical applications of nitric oxide-containing air-plasma gas flow generated by Plason device

Alexandra V. Butenko et al.

CLINICAL PLASMA MEDICINE (2020)

Review Chemistry, Multidisciplinary

Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Roy Weinstain et al.

CHEMICAL REVIEWS (2020)

Article Biochemistry & Molecular Biology

Controlled Nitric Oxide Release Using Poly(lactic-co-glycolic acid) Nanoparticles for Anti-Inflammatory Effects

Yoogyeong Oh et al.

BIOMACROMOLECULES (2020)

Review Pharmacology & Pharmacy

A recent history of nitroxyl chemistry, pharmacology and therapeutic potential

Jon M. Fukuto

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Long-term decomposition of aqueous S-nitrosoglutathione and S-nitroso-N-acetylcysteine: Influence of concentration, temperature, pH and light

Gabriela Freitas P. de Souza et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Review Chemistry, Organic

Methods for Hydroxamic Acid Synthesis

Mohammad A. Alam

CURRENT ORGANIC CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases

Jesus Tejero et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Medicine, Research & Experimental

Incorporation of Nitroprusside on Silica Nanoparticles-A Strategy for Safer Use of This NO Donor in Therapy

Pedro M. Silva Filho et al.

MOLECULAR PHARMACEUTICS (2019)

Article Pharmacology & Pharmacy

Nitric oxide-enhancing or -releasing agents as antithrombotic drugs

P. Gresele et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Structural insights into the mechanism of human soluble guanylate cyclase

Yunlu Kang et al.

NATURE (2019)

Article Chemistry, Multidisciplinary

Targeted photoredox catalysis in cancer cells

Huaiyi Huang et al.

NATURE CHEMISTRY (2019)

Article Chemistry, Medicinal

Design, synthesis and evaluation of belinostat analogs as histone deacetylase inhibitors

Jie-Huan Zhang et al.

FUTURE MEDICINAL CHEMISTRY (2019)

Review Pharmacology & Pharmacy

Nitric oxide synthase enzymology in the 20 years after the Nobel Prize

Dennis J. Stuehr et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Structural Insight into H-NOX Gas Sensing and Cognate Signaling Protein Regulation

Yirui Guo et al.

CHEMBIOCHEM (2019)

Article Chemistry, Medicinal

Nitro-Group-Containing Drugs

Kunal Nepali et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Pharmacokinetics and pharmacodynamics of nitric oxide mimetic agents

Austin Horton et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Article Chemistry, Inorganic & Nuclear

Comparison of Carbazole and Fluorene Donating Effects on the Two-Photon Absorption and Nitric Oxide Photorelease Capabilities of a Ruthenium-Nitrosyl Complex

Alejandro Enriquez-Cabrera et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2018)

Article Nanoscience & Nanotechnology

Comparison of Copper(II)-Ligand Complexes as Mediators for Preparing Electrochemically Modulated Nitric Oxide-Releasing Catheters

Kamila K. Konopinska et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Review Medicine, General & Internal

Vasodilators in acute heart failure - evidence based on new studies

Andre M. Travessa et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2018)

Article Biochemistry & Molecular Biology

Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity

Carlos D. S. Silva et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2018)

Review Chemistry, Medicinal

Recent Developments in Drug Design of NO-donor Hybrid Compounds

Rajan Sharma et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Physiological activation and deactivation of soluble guanylate cyclase

Benjamin G. Horst et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Article Immunology

Evaluation of nitroxyl donors' effect on mycobacteria

Jordana Galizia et al.

TUBERCULOSIS (2018)

Article Chemistry, Multidisciplinary

Development and cellular application of visiblelight- controllable HNO releasers based on caged Piloty's acid

Mitsuyasu Kawaguchi et al.

CHEMICAL COMMUNICATIONS (2018)

Review Chemistry, Inorganic & Nuclear

Metal complex strategies for photo-uncaging the small molecule bioregulators nitric oxide and carbon monoxide

Peter C. Ford

COORDINATION CHEMISTRY REVIEWS (2018)

Article Engineering, Environmental

Efficient Bacterial Inactivation by Transition Metal Catalyzed Auto-Oxidation of Sulfite

Long Chen et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Review Chemistry, Inorganic & Nuclear

Transition-Metal Nitrosyls for Photocontrolled Nitric Oxide Delivery

Hui-Jing Xiang et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Drug discovery targeting heme-based sensors and their coupled activities

Eduardo Henrique Silva Sousa et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2017)

Article Chemistry, Medicinal

Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives

Gebremedhin S. Hailu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Chemistry, Inorganic & Nuclear

Advances in the design of organometallic anticancer complexes

Pingyu Zhang et al.

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2017)

Article Pharmacology & Pharmacy

The opposing roles of NO and oxidative stress in cardiovascular disease

Rebecca H. Ritchie et al.

PHARMACOLOGICAL RESEARCH (2017)

Article Cardiac & Cardiovascular Systems

Clinical Effectiveness of Hydralazine-Isosorbide Dinitrate in African-American Patients With Heart Failure

Boback Ziaeian et al.

JACC-HEART FAILURE (2017)

Article Multidisciplinary Sciences

Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity

Sonia Donzelli et al.

SCIENTIFIC REPORTS (2017)

Review Chemistry, Multidisciplinary

S-Nitrosothiols: chemistry and reactions

Caihong Zhang et al.

CHEMICAL COMMUNICATIONS (2017)

Review Chemistry, Multidisciplinary

Generation and Trapping of Nitrosocarbonyl Intermediates

Misal Giuseppe Memeo et al.

CHEMICAL REVIEWS (2017)

Review Medicine, Research & Experimental

Therapeutic role of nitric oxide as emerging molecule

Sahil Kumar et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Biochemistry & Molecular Biology

Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1α Inhibition for Cancer Therapy

Eduardo Henrique Silva Sousa et al.

ACS CHEMICAL BIOLOGY (2016)

Article Chemistry, Multidisciplinary

Emerging Targets in Photopharmacology

Michael M. Lerch et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Biotechnology & Applied Microbiology

Nitric oxide signaling in yeast

Rika Indri Astuti et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Pharmacology & Pharmacy

S-Nitrosothiols as Platforms for Topical Nitric Oxide Delivery

Marcelo Ganzarolli de Oliveira

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2016)

Review Oncology

Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia

Elena Ceccacci et al.

BRITISH JOURNAL OF CANCER (2016)

Review Chemistry, Inorganic & Nuclear

New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

Maykon Lima Souza et al.

COORDINATION CHEMISTRY REVIEWS (2016)

Review Chemistry, Inorganic & Nuclear

Recent advances in multinuclear metal nitrosyl complexes

Lijuan Li et al.

COORDINATION CHEMISTRY REVIEWS (2016)

Article Chemistry, Physical

Evaluation of Methods for the Calculation of the pKa of Cysteine Residues in Proteins

Ernest Awoonor-Williams et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2016)

Article Biochemistry & Molecular Biology

Is photoisomerization required for NO photorelease in ruthenium nitrosyl complexes?

Juan Sanz Garcia et al.

JOURNAL OF MOLECULAR MODELING (2016)

Article Chemistry, Multidisciplinary

Synthesis of CoII-NO- Complexes and Their Reactivity as a Source of Nitroxyl

Melody R. Walter et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Review Biochemistry & Molecular Biology

Recent advances in the chemical biology of nitroxyl (HNO) detection and generation

Zhengrui Miao et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2016)

Article Chemistry, Multidisciplinary

Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles

Thuy-Khanh Nguyen et al.

CHEMICAL SCIENCE (2016)

Article Cardiac & Cardiovascular Systems

Discovery and Clinical Evaluation of MK-8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

Clayton D. Knox et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Review Chemistry, Multidisciplinary

Heme-Nitrosyls: Electronic Structure Implications for Function in Biology

Andrew P. Hunt et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

New acyloxy nitroso compounds with improved water solubility and nitroxyl (HNO) release kinetics and inhibitors of platelet aggregation

Heba A. H. Mohamed et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Colin Fowley et al.

CHEMICAL COMMUNICATIONS (2015)

Article Chemistry, Multidisciplinary

Sensitization of NO-Releasing Ruthenium Complexes to Visible Light

Tobias Becker et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

Article Chemistry, Inorganic & Nuclear

Nitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)4P(OEt)3](PF6)3

Jose Clayston Melo Pereira et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

The basics of thiols and cysteines in redox biology and chemistry

Leslie B. Poole

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Chemistry, Inorganic & Nuclear

Does Perthionitrite (SSNO-) Account for Sustained Bioactivity of NO? A (Bio)chemical Characterization

Rudolf Wedmann et al.

INORGANIC CHEMISTRY (2015)

Article Chemistry, Organic

Curtailing the Hydroxylaminobarbituric Acid-Hydantoin Rearrangement To Favor HNO Generation

Daryl A. Guthrie et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Organic

Catch-and-Release of HNO with Pyrazolones

Daryl A. Guthrie et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Multidisciplinary Sciences

Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl

Miriam M. Cortese-Krott et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Chemistry, Multidisciplinary

Electron Flow through Metalloproteins

Jay R. Winkler et al.

CHEMICAL REVIEWS (2014)

Article Biochemistry & Molecular Biology

Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide

Yuval Samuni et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Article Chemistry, Inorganic & Nuclear

Theoretical Spectroscopy and Photodynamics of a Ruthenium Nitrosyl Complex

Leon Freitag et al.

INORGANIC CHEMISTRY (2014)

Article Chemistry, Inorganic & Nuclear

trans-[Ru(NO)(NH3)P(O-)(OEt)2]2+: A new and robust NO/ HNO-donor

Daniela R. Truzzi et al.

INORGANICA CHIMICA ACTA (2014)

Article Biochemistry & Molecular Biology

Nitroxyl (HNO) Reacts with Molecular Oxygen and Forms Peroxynitrite at Physiological pH BIOLOGICAL IMPLICATIONS

Renata Smulik et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Decomposition of amino diazeniumdiolates (NONOates): Molecular mechanisms

Nizamuddin Shaikh et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

A comparative study of NONOate based NO donors: Spermine NONOate is the best suited NO donor for angiogenesis

Syamantak Majumder et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates

Gaurav Bharadwaj et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

Article Chemistry, Organic

A fluorescent probe for intracellular cysteine overcoming the interference by glutathione

Minggang Tian et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

Review Pharmacology & Pharmacy

Organic nitrates: Update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction

Thomas Muenzel et al.

VASCULAR PHARMACOLOGY (2014)

Article Multidisciplinary Sciences

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway

Mirjam Eberhardt et al.

NATURE COMMUNICATIONS (2014)

Review Chemistry, Multidisciplinary

Hydroxamic Acids in Asymmetric Synthesis

Zhi Li et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

Article Chemistry, Multidisciplinary

The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators

Markus Follmann et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Biochemistry & Molecular Biology

Hydroxylamine acutely activates glucose uptake in L929 fibroblast cells

Larry L. Louters et al.

BIOCHIMIE (2013)

Article Chemistry, Medicinal

Piloty's acid derivative with improved nitroxyl-releasing characteristics

Kazuyuki Aizawa et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Chemistry, Multidisciplinary

Exploration of the medical periodic table: towards new targets

Nicolas P. E. Barry et al.

CHEMICAL COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Cytotoxicity of nitroxyl (HNO/NO-) against normal and cancer human cells

Aleksandra Augustyniak et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2013)

Article Cardiac & Cardiovascular Systems

Nitroxyl (HNO)

Hani N. Sabbah et al.

CIRCULATION-HEART FAILURE (2013)

Article Cardiac & Cardiovascular Systems

Nitroglycerine and sodium trioxodinitrate: from the discovery to the preconditioning effect

Pasquale Pagliaro et al.

JOURNAL OF CARDIOVASCULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

The pH of HNO donation is modulated by ring substituents in Piloty's acid derivatives: azanone donors at biological pH

Kiran Sirsalmath et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2013)

Review Biochemistry & Molecular Biology

A comparison of the chemistry associated with the biological signaling and actions of nitroxyl (HNO) and nitric oxide (NO)

Jon M. Fukuto et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2013)

Review Chemistry, Medicinal

Organic Nitrate Metabolism and Action: Toward a Unifying Hypothesis and the Future-A Dedication to Professor Leslie Z. Benet

Nathaniel A. Page et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Article Neurosciences

The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats

Ana C. Zarpelon et al.

NEUROPHARMACOLOGY (2013)

Review Biochemistry & Molecular Biology

Photochemical delivery of nitric oxide

Peter C. Ford

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2013)

Review Multidisciplinary Sciences

Light-triggered nitric oxide delivery to malignant sites and infection

Brandon Heilman et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2013)

Article Pharmacology & Pharmacy

Pharmacological Characterization of 1-Nitrosocyclohexyl Acetate, a Long-Acting Nitroxyl Donor That Shows Vasorelaxant and Antiaggregatory Effects

Sonia Donzelli et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)

Article Gastroenterology & Hepatology

Advance in Photosensitizers and Light Delivery for Photodynamic Therapy

Il Yoon et al.

CLINICAL ENDOSCOPY (2013)

Article Biochemistry & Molecular Biology

Reactivity of Nitroxyl-Derived Sulfinamides

Gizem Keceli et al.

BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Diazeniumdiolated carbamates: A novel class of nitric oxide donors

Rahul S. Nandurdikar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

The Molecular Design of S-Nitrosothiols as Photodynamic Agents for Controlled Nitric Oxide Release

Niroshini M. Giles et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2012)

Article Cardiac & Cardiovascular Systems

Nitroxyl-Mediated Disulfide Bond Formation Between Cardiac Myofilament Cysteines Enhances Contractile Function

Wei Dong Gao et al.

CIRCULATION RESEARCH (2012)

Review Biochemistry & Molecular Biology

Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling

Brian C. Smith et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2012)

Review Cardiac & Cardiovascular Systems

Nitric oxide synthases: regulation and function

Ulrich Foerstermann et al.

EUROPEAN HEART JOURNAL (2012)

Article Biochemistry & Molecular Biology

Nitrogen dioxide oxidizes mitochondrial cytochrome c

Rebecca S. Silkstone et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Chemistry, Multidisciplinary

Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols

Milos R. Filipovic et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Biochemistry & Molecular Biology

Preconditioning with a Novel Metallopharmaceutical NO Donor in Anesthetized Rats Subjected to Brain Ischemia/Reperfusion

Marcio Wilker Soares Campelo et al.

NEUROCHEMICAL RESEARCH (2012)

Review Biochemistry & Molecular Biology

Biological activity of ruthenium nitrosyl complexes

Elia Tfouni et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2012)

Review Chemistry, Multidisciplinary

Photoactive Ruthenium Nitrosyls as NO Donors: How To Sensitize Them toward Visible Light

Nicole L. Fry et al.

ACCOUNTS OF CHEMICAL RESEARCH (2011)

Article Chemistry, Multidisciplinary

Addition and Redox Reactivity of Hydrogen Sulfides (H2S/HS-) with Nitroprusside: New Chemistry of Nitrososulfide Ligands

Sandra L. Quiroga et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

Article Biochemistry & Molecular Biology

Detection of nitroxyl (HNO) by membrane inlet mass spectrometry

Meredith R. Cline et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Chemistry, Inorganic & Nuclear

HNO and NO Release from a Primary Amine-Based Diazeniumdiolate As a Function of pH

Debra J. Salmon et al.

INORGANIC CHEMISTRY (2011)

Article Chemistry, Inorganic & Nuclear

Mechanism of NO Photodissociation in Photo labile Manganese-NO Complexes with Pentadentate N5 Ligands

Anna C. Merkle et al.

INORGANIC CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Mechanism and biological implications of the NO release of cis-[Ru(bpy)2L(NO)]n+ complexes: A key role of physiological thiols

Francisco O. N. Silva et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2011)

Article Chemistry, Medicinal

Acyloxy Nitroso Compounds as Nitroxyl (HNO) Donors: Kinetics, Reactions with Thiols, and Vasodilation Properties

Mai E. Shoman et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Pharmacology & Pharmacy

Characterization of Pharmacological and Wake-Promoting Properties of the Dopaminergic Stimulant Sydnocarb in Rats

John A. Gruner et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Article Medicine, Research & Experimental

Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats

Ipek Komsuoglu-Celikyurt et al.

LIFE SCIENCES (2011)

Article Mycology

Experimental Chemotherapy in Paracoccidioidomycosis Using Ruthenium NO Donor

Wander Rogerio Pavanelli et al.

MYCOPATHOLOGIA (2011)

Review Cell Biology

Hydrogen peroxide: a Jekyll and Hyde signalling molecule

D. R. Gough et al.

CELL DEATH & DISEASE (2011)

Article Pharmacology & Pharmacy

Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity

Jean Jerley Nogueira Silva et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Chemistry, Multidisciplinary

Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity

Kazuya Matsuo et al.

CHEMICAL COMMUNICATIONS (2010)

Article Chemistry, Multidisciplinary

Dual Mechanisms of HNO Generation by a Nitroxyl Prodrug of the Diazeniumdiolate (NONOate) Class

Daniela Andrei et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase

Joshua J. Woodward et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Review Biochemistry & Molecular Biology

NO synthase: Structures and mechanisms

Simon Daff

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2010)

Article Chemistry, Inorganic & Nuclear

NO donors cis-[Ru(bpy)2(L)NO]3+ and [Fe(CN)4(L)NO]- complexes immobilized on modified mesoporous silica spheres

Francisco O. N. da Silva et al.

POLYHEDRON (2010)

Article Cardiac & Cardiovascular Systems

The shy Angeli and his elusive creature: the HNO route to vasodilation

Nazareno Paolocci et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Review Multidisciplinary Sciences

Metalloproteins and metal sensing

Kevin J. Waldron et al.

NATURE (2009)

Review Biochemistry & Molecular Biology

Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications

Li Zhou et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction

Yusuke Adachi et al.

CHEMICAL COMMUNICATIONS (2008)

Review Chemistry, Inorganic & Nuclear

Photoactive ruthenium nitrosyls: Effects of light and potential application as NO donors

Michael J. Rose et al.

COORDINATION CHEMISTRY REVIEWS (2008)

Review Biochemistry & Molecular Biology

Fiat Lux: selective delivery of high flux of nitric oxide (NO) to biological targets using photoactive metal nitrosyls

Michael J. Rose et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2008)

Article Respiratory System

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

R. T. Schermuly et al.

EUROPEAN RESPIRATORY JOURNAL (2008)

Article Biochemistry & Molecular Biology

Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine

Sonia Donzelli et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Review Chemistry, Medicinal

Histone deacetylase inhibitors: From bench to clinic

Marielle Paris et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Chemistry, Multidisciplinary

Near-infrared light activated release of nitric oxide from designed photoactive manganese nitrosyls: Strategy, design, and potential as NO donors

Aura A. Eroy-Reveles et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Multidisciplinary Sciences

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

Ramandeep Singh et al.

SCIENCE (2008)

Article Oncology

Nitroxyl inhibits breast tumor growth and angiogenesis

Andrew J. Norris et al.

INTERNATIONAL JOURNAL OF CANCER (2008)

Review Pharmacology & Pharmacy

Review - Recent developments in nitric oxide donor drugs

M. R. Miller et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Review Biochemistry & Molecular Biology

Molecular targeting of proteins by L-homocysteine: Mechanistic implications for vascular disease

Alla V. Glushchenko et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Article Biochemistry & Molecular Biology

The inhibition of glyceraldehyde-3-phosphate dehydrogenase by nitroxyl (HNO)

Brenda E. Lopez et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)

Review Biochemistry & Molecular Biology

Discovery and development of SAHA as an anticancer agent

P. A. Marks

ONCOGENE (2007)

Review Pharmacology & Pharmacy

The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO

Nazareno Paolocci et al.

PHARMACOLOGY & THERAPEUTICS (2007)

Article Biochemistry & Molecular Biology

Esterase-activated chromane-sydnonimine prodrug hybrids

Virginie Vinatier et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Peroxynitrite and myocardial contractility: In vivo versus in vitro effects

Tatsuo Katori et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Review Hematology

Tetrahydrobiopterin and cardiovascular disease

An L. Moens et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

Article Chemistry, Multidisciplinary

Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO)

Xin Sha et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

Article Chemistry, Multidisciplinary

Release of nitric oxide from a sol-gel hybrid material containing a photoactive manganese nitrosyl upon illumination with visible light

Aura A. Eroy-Reveles et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

Article Chemistry, Inorganic & Nuclear

Synthesis, characterization, and NO release study of the cis- and trans-[Ru(Bpy)2(SO3)(NO)]+ complexes

Francisco O. N. Silva et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2006)

Article Pharmacology & Pharmacy

Redox modifications of protein-thiols: Emerging roles in cell signaling

S Biswas et al.

BIOCHEMICAL PHARMACOLOGY (2006)

Article Biochemistry & Molecular Biology

Detection of nitrous oxide in the neuronal nitric oxide synthase reaction by gas chromatography-mass spectrometry

Y Ishimura et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Neurosciences

Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase

Y Kamada et al.

MOLECULAR BRAIN RESEARCH (2005)

Article Chemistry, Multidisciplinary

Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols

DA Stoyanovsky et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Biochemistry & Molecular Biology

Inhibition of yeast glycolysis by nitroxyl (HNO): A mechanism of HNO toxicity and implications to HNO biology

BE Lopez et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)

Article Cardiac & Cardiovascular Systems

Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis

M Sekiya et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2005)

Article Chemistry, Inorganic & Nuclear

The reactions of nitrosyl complexes with cysteine

F Roncaroli et al.

INORGANIC CHEMISTRY (2005)

Article Chemistry, Organic

New glycosidase activated nitric oxide donors: Glycose and 3-morphorlinosydnonimine conjugates

TB Cai et al.

JOURNAL OF ORGANIC CHEMISTRY (2005)

Review Chemistry, Inorganic & Nuclear

The chemistry of nitroxyl (HNO) and implications in biology

KM Miranda

COORDINATION CHEMISTRY REVIEWS (2005)

Review Pharmacology & Pharmacy

Cardioprotective effects of glyceryl trinitrate: beyond vascular nitrate tolerance

T Csont et al.

PHARMACOLOGY & THERAPEUTICS (2005)

Review Chemistry, Medicinal

N-hydroxyurea and acyl nitroso compounds as nitroxyl (HNO) and nitric oxide (NO) donors

SB King

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Xanthine oxidase converts nitric oxide to nitroxyl that inactivates the enzyme

M Saleem et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Pharmacology & Pharmacy

Continuous administration of organic nitrate decreases hepatic cytochrome P450

Y Minamiyama et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)

Article Chemistry, Medicinal

Nitroxyl (HNO) release from new functionalized N-hydroxyurea-derived acyl nitroso-9,10-dimethylanthracene cycloadducts

BB Zeng et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

Article Chemistry, Medicinal

Effects of pH on the cytotoxicity of sodium trioxodinitrate (Angeli's salt)

DA Stoyanovsky et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Article Cell Biology

Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases

E Metzen et al.

MOLECULAR BIOLOGY OF THE CELL (2003)

Review Biochemistry & Molecular Biology

Shedding light onto live molecular targets

Ralph Weissleder et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning

P Pagliaro et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Review Chemistry, Inorganic & Nuclear

Structure, chemical and photochemical reactivity and biological activity of some ruthenium amine nitrosyl complexes

E Tfouni et al.

COORDINATION CHEMISTRY REVIEWS (2003)

Article Cardiac & Cardiovascular Systems

S-nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty

Z Kaposzta et al.

CIRCULATION (2002)

Article Multidisciplinary Sciences

Nitroxyl and its anion in aqueous solutions: Spin states, protic equilibria, and reactivities toward oxygen and nitric oxide

V Shafirovich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Chemistry, Multidisciplinary

Nitric oxide donors: Chemical activities and biological applications

PG Wang et al.

CHEMICAL REVIEWS (2002)

Article Biochemistry & Molecular Biology

Copper,zinc superoxide dismutase as a univalent NO- oxidoreductase and as a dichlorofluorescin peroxidase

SI Liochev et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Reaction mechanism between nitric oxide and glutathione mediated by Fe(III) myoglobin

G Reichenbach et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2001)

Article Chemistry, Multidisciplinary

Chemistry of the diazeniumdiolates. 2. Kinetics and mechanism of dissociation to nitric oxide in aqueous solution

KM Davies et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)

Review Toxicology

The toxicology of inhaled nitric oxide

B Weinberger et al.

TOXICOLOGICAL SCIENCES (2001)

Article Biochemistry & Molecular Biology

Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase - Implications for mechanism

S Adak et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Chemistry, Inorganic & Nuclear

Nitrosyl transfer from manganese to iron in tropocoronand complexes

KJ Franz et al.

INORGANIC CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

The reaction mechanism of nitrosothiols with copper(I)

A Burg et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2000)