Accuracy of saliva and nasopharyngeal sampling for detection of SARS-CoV-2 in community screening: a multicentric cohort study

Article Infectious Diseases

Saliva sample as a non-invasive specimen for the diagnosis of coronavirus disease 2019: a cross-sectional study

E. Pasomsub et al.

Summary: Saliva may serve as an alternative specimen for the diagnosis of COVID-19, with high sensitivity and specificity compared to nasopharyngeal and throat swab RT-PCR.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Immunology

Comparing Nasopharyngeal Swab and Early Morning Saliva for the Identification of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Mohan Rao et al.

Summary: This study shows that saliva is a better alternative specimen for detecting SARS-CoV-2. The detection rate of SARS-CoV-2 was higher in saliva compared to NPS, and saliva collection is simple and can reduce exposure to healthcare workers.

CLINICAL INFECTIOUS DISEASES (2021)

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Letter Medicine, General & Internal

Salivary Detection of COVID-19

Lisa Caulley et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Immunology

Mass Screening of Asymptomatic Persons for Severe Acute Respiratory Syndrome Coronavirus 2 Using Saliva

Isao Yokota et al.

Summary: This mass screening study showed that both NPS and saliva specimens had high sensitivity and specificity, with self-collected saliva specimens being valuable for detecting SARS-CoV-2 in mass screening of asymptomatic individuals. Viral load was highly correlated between NPS and saliva specimens in individuals testing positive.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Self-Collected Oral Fluid and Nasal Swabs Demonstrate Comparable Sensitivity to Clinician Collected Nasopharyngeal Swabs for Coronavirus Disease 2019 Detection

N. Kojima et al.

Summary: Both supervised oral fluid and nasal swab specimens performed similarly to clinician-collected nasopharyngeal swab specimens in detecting SARS-CoV-2, and none of the positive participants were detected using any sample type.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Antigen-Based Testing but Not Real-Time Polymerase Chain Reaction Correlates With Severe Acute Respiratory Syndrome Coronavirus 2 Viral Culture

Andrew Pekosz et al.

Summary: Recent studies indicate that SARS-CoV-2 antigen testing demonstrates a higher positive predictive value in the early stages of infection and shows good consistency with culture results. This testing method can significantly aid in determining the risk of carrying infectious virus.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Infectious Diseases

Impact of mass testing during an epidemic rebound of SARS-CoV-2: a modelling study using the example of France

Paolo Bosetti et al.

Summary: Mass testing is effective in controlling the epidemic growth when it is limited, but frequent testing is necessary to achieve control.

EUROSURVEILLANCE (2021)

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Article Microbiology

Comparison of the Quidel Sofia SARS FIA Test to the Hologic Aptima SARS-CoV-2 TMA Test for Diagnosis of COVID-19 in Symptomatic Outpatients

Eric T. Beck et al.

Summary: The study compared the Quidel Sofia SARS-CoV-2 antigen rapid test with the Hologic Aptima SARS-CoV-2 nucleic acid molecular diagnostic test. The results showed a higher agreement between the SOFIA test and APTIMA TMA test in symptomatic patients, with a positive percent agreement of 82.0% in patients tested within 5 days of symptom onset.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Review Medicine, General & Internal

Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2 A Systematic Review and Meta-analysis

Guillaume Butler-Laporte et al.

Summary: This study evaluated the diagnostic accuracy of saliva NAAT for COVID-19 and found that its accuracy is similar to that of nasopharyngeal swab NAAT, especially in ambulatory settings. This suggests the potential for saliva NAAT as an alternative to nasopharyngeal swabs and supports further research in this area.

JAMA INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Clinical and Economic Effects of Widespread Rapid Testing to Decrease SARS-CoV-2 Transmission

A. David Paltiel et al.

Summary: The study suggests that high-frequency home testing for SARS-CoV-2 with an inexpensive, imperfect test can reduce infections, deaths, and hospitalizations at justifiable cost.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Quantifying the potential value of antigen-detection rapid diagnostic tests for COVID-19: a modelling analysis

Saskia Ricks et al.

Summary: Antigen-detection rapid diagnostic tests (Ag-RDTs) have been found to offer greater public health value than nucleic acid tests (NATs) in COVID-19 testing, with potential for more impactful outcomes and lower cost per death and infectious person-days averted. In hospital settings, an Ag-RDT-led strategy may avert more deaths when clinical judgement sensitivity is below 90% and when NAT results are not available in time for most patients. In community settings, Ag-RDTs are robustly supported as they can prevent more transmission at a lower cost compared to relying solely on NAT.

BMC MEDICINE (2021)

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Article Infectious Diseases

Saliva for molecular detection of SARS-CoV-2 in school-age children

Hanan Al Suwaidi et al.

Summary: The study aimed to determine the diagnostic accuracy of saliva for SARS-CoV-2 RT-PCR in children, with findings suggesting a high sensitivity and specificity, making saliva a recommended diagnostic specimen for COVID-19 screening in children.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Review Infectious Diseases

Nucleic acid amplification tests on respiratory samples for the diagnosis of coronavirus infections: a systematic review and meta-analysis

Mona Mustafa Hellou et al.

Summary: This study evaluated the diagnostic test accuracy of nucleic acid amplification tests (NAATs) for coronavirus infections and found that real-time RT-PCR assays have higher sensitivity. The pooled results indicated that on average 10% of patients with coronavirus infections might be missed with PCR tests.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Microbiology

Evaluation of Specimen Types and Saliva Stabilization Solutions for SARS-CoV-2 Testing

Sara B. Griesemer et al.

Summary: Identifying SARS-CoV-2 infections through aggressive diagnostic testing is crucial in tracking and controlling the spread of COVID-19. Alternative specimen types like nasal swabs and saliva have been investigated for detection sensitivity, with combining the two sample types resulting in improved sensitivity. Additionally, stabilizing solutions did not enhance virus stability in saliva.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Immunology

Think of the Children Evaluation of SARS-CoV-2 Rapid Antigen Test in Pediatric Population

Patricia Gonzalez-Donapetry et al.

Summary: This study evaluated the performance of the Panbio COVID-19 Ag Rapid Test Device in diagnosing SARS-CoV-2 in pediatric population, with a sensitivity of 77.7% and good specificity, negative and positive predictive values.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2021)

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Article Public, Environmental & Occupational Health

Comparative cost-effectiveness of SARS-CoV-2 testing strategies in the USA: a modelling study

Zhanwei Du et al.

Summary: This study aimed to evaluate the economic trade-offs of expanding and accelerating testing for SARS-CoV-2 across the USA in different transmission scenarios. The findings suggest that weekly testing combined with a 2-week isolation period is the most cost-effective strategy under rapid transmission scenarios, while monthly testing with a 1-week isolation period is most cost-effective under low transmission scenarios.

LANCET PUBLIC HEALTH (2021)

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Article Immunology

Antigen-Based Testing but Not Real-Time Polymerase Chain Reaction Correlates With Severe Acute Respiratory Syndrome Coronavirus 2 Viral Culture

Andrew Pekosz et al.

Summary: SARS-CoV-2 antigen testing may be positive early in the disease course, aiding in determining infectious risk, with a slightly better detection of infectious virus compared to rt-PCR.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Medicine, General & Internal