Clinical evaluation of rapid point-of-care antigen tests for diagnosis of SARS-CoV-2 infection

Article Multidisciplinary Sciences

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Jeroen J. A. van Kampen et al.

Summary: The study found that the median duration of shedding infectious virus in COVID-19 patients is 8 days, dropping below 5% after 15.2 days post onset of symptoms. High viral loads are associated with infectious SARS-CoV-2 isolation, while high serum neutralizing antibody titres are associated with non-infectious SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

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Article Public, Environmental & Occupational Health

Performance of an Antigen-Based Test for Asymptomatic and Symptomatic SARS-CoV-2 Testing at Two University Campuses - Wisconsin, September-October 2020

Ian W. Pray et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Infectious Diseases

Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres

Eliseo Albert et al.

Summary: The Panbio (TM) COVID-19 Ag Rapid Test Device performed well as a POC test for early diagnosis of COVID-19 in primary healthcare centres, with a specificity and sensitivity of 100% and 79.6% respectively. The negative predictive value of RAD was 99% and 97.9% under estimated prevalence of 5% and 10% respectively.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Infectious Diseases

Multicenter evaluation of the Panbio™ COVID-19 rapid antigen-detection test for the diagnosis of SARS-CoV-2 infection

Paloma Merino et al.

Summary: The study aimed to evaluate the performance of the PanbioRT COVID-19 Ag Rapid Test Device in detecting SARS-CoV-2 in patients with COVID-19 symptoms. The results showed that PanbioRT performed well clinically, especially for patients with a shorter clinical course or a higher viral load.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Biochemical Research Methods

Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit

Alexander Kruettgen et al.

Summary: The study found that the specificity of the SARS-CoV-2 Rapid Antigen Test is higher than its sensitivity, with high accuracy for samples with a cycle threshold of less than 25. It is suitable for differentiating contagious and non-contagious SARS-CoV-2 patients.

JOURNAL OF VIROLOGICAL METHODS (2021)

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Article Infectious Diseases

Comparative evaluation of four SARS-CoV-2 antigen tests in hospitalized patients

Lis Thommes et al.

Summary: The study evaluated the clinical performance of four commercially available antigen tests in hospitalized COVID-19 patients. Most antigen tests had sufficient sensitivity to identify subjects infected with SARS-CoV-2 and with transmissible infection, but may not accurately identify patients who have lost infectivity.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands

Nathalie Van der Moeren et al.

Summary: The study found that the VRD is a promising diagnostic for COVID-19 testing of symptomatic community-dwelling individuals within seven days after symptom onset, showing high sensitivity and specificity. Further research on practical applicability and optimal positioning within the testing landscape is needed.

PLOS ONE (2021)

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Article Medicine, General & Internal

Real-life validation of the Panbio™ COVID-19 antigen rapid test (Abbott) in community-dwelling subjects with symptoms of potential SARS-CoV-2 infection

Hendrik Gremmels et al.

Summary: The antigen rapid test showed high specificity and sensitivity in community-dwelling residents in the Netherlands and Aruba, especially when using a Ct value <32 cycles as the cut-off for RT-qPCR positivity. This test could play a significant role in controlling viral spread.

ECLINICALMEDICINE (2021)

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Article Infectious Diseases