4.7 Article

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

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Summary: The rapidly evolving field of immunometabolism has highlighted the key signaling roles of metabolites in cellular communication, with recent evidence focusing on the succinate-SUCNR1 axis as a crucial regulator of tissue homeostasis. Succinate signaling through SUCNR1 guides diverse immune cell responses, which are influenced by tissue and context. This research explores cellular pathways regulated by the succinate-SUCNR1 axis and its impact on myeloid cell function, aiming to identify new therapeutic targets for addressing detrimental myeloid cell responses in tissues, including those in the persistently inflamed central nervous system (CNS).

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