Journal
EPILEPTIC DISORDERS
Volume 23, Issue 3, Pages 476-484Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/epd.2021.1289
Keywords
temporal lobe epilepsy; pilocarpine-induced model of epilepsy; cognitive impairment; fish oil supplementation; Morris Water Mazer; spatial learning and memory
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Funding
- Coordination for the Improvement of Higher Education Personnel (CAPES)
- Sao Paulo Research Foundation (FAPESP) [2016/17746-3, 2018/18568-7, 2016/06879-2]
- National Council for Scientific and Technological Development (CNPq) [405811/2018-7, 311251/2017]
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This study highlights the importance of considering nutraceutical strategies to enhance cognitive abilities in patients with TLE.
Objective. Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy. Methods. We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test. Results. Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials. Significance. Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE.
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