International Consortium to Advance Cross-Species Extrapolation of the Effects of Chemicals in Regulatory Toxicology

Article Engineering, Environmental

Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Species

Maria Sapounidou et al.

Summary: This study developed a new classification scheme to group chemicals based on their toxicological mechanisms, with detailed categorization into three broad domains representing non-specific toxicity, reactive mechanisms, and specific mechanisms. The novelty of this approach lies in its reference to taxonomic diversity, transparency, quality of supporting evidence on molecular initiating events, and its ease of updating.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

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Article Toxicology

Integrative Computational Approaches to Inform Relative Bioaccumulation Potential of Per- and Polyfluoroalkyl Substances Across Species

Weixiao Cheng et al.

Summary: Predictive toxicology relies on computational methods to address important questions in chemicals assessment. By evaluating cross-species differences in binding affinity between per- and polyfluoroalkyl substances and liver fatty acid-binding protein, insights can be gained for ecosystem protection and selection of appropriate model species for human toxicity studies.

TOXICOLOGICAL SCIENCES (2021)

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Article Toxicology