Bioremediation role of Spirulina platensis against deltamethrin-mediated toxicity and its chemical residues in chicken meat

Deltamethrin (DM) is a synthetic pyrethroid insecticide commonly used in veterinary and agriculture. However, both animal and human exposure are associated with hepatorenal toxicity. Our experimental goal was to assess the protective effects of Spirulina platensis (SP) against DM-induced hepatorenal injury, growth performance, meat chemical composition, and its residues in meat, liver, and skin of broiler chickens. Sixty 1-day-old Cobb broiler chicks were assigned to 4 experimental groups; each was divided into 3 replicates with five chicks each; the 1st group received basal diet alone (control), 2nd group supplemented with SP 20 g/kg diet, 3rd group supplemented with DM 300 mg/kg diet, and 4th group supplemented with DM and SP diet. All groups have received the treatment for 35 days. DM, decreased body weight, weight gain, and increased feed conversion rate. DM showed a significant increase in ALT, AST, urea, creatinine, and MDA and a significant decrease in SOD, and GSH levels. Also, SP significantly reduced DM levels in meat, skin, and liver with a reduction 63.01, 63.00, and 62.90 %, respectively. The DM intoxicated group showed a significant decrease in protein and a marked increase in fat, cholesterol, and triglycerides when compared to the control group. Histopathological changes were also recorded. Dietary SP improved these parameters. Dietary inclusion of SP can be recommended due to the protective effects on DM-induced toxicity in broiler chickens.

Automated summary

The study showed that Spirulina platensis has protective effects against DM-induced hepatorenal injury in broiler chickens, reducing DM residues in meat, skin, and liver, improving meat composition, and growth performance.