Association of maternal exposure to bisphenol A with her β-hCG level and neonatal anthropometric measures

Bisphenol A (BPA) is one of the organic compounds that might interfere with estrogenic receptors, which would make difficulties in pregnancy hormones and fetal growth. Human chorionic gonadotropin (beta-hCG) is one of the important pregnancy hormones that might be affected by environmental pollutants. The aim of this study is to investigate the probable impacts of maternal exposure to BPA on anthropometric measures of newborns. This cross-sectional study was conducted in 2019-2020 in Isfahan, Iran. During the first trimester of pregnancy, we measured the urinary BPA concentration and serum beta-hCG level of 120 pregnant women, who were randomly selected from participants of a birth cohort. BPA concentration was measured using gas chromatography-mass spectrometry (GC-MS). Serum blood sample was derived and used for beta-hCG analysis. Anthropometric measurement of neonates was conducted at the time of birth. BPA and beta-hCG level were grouped by quartiles, and their associations with birth weight, height, and head circumference were tested using multiple linear regression model. The adjustment was done for urine creatinine, gender, and gestational age, as well as maternal age, body mass index, and education level. Data of 119 pairs of mothers and infants were available for the present study. The mean (SD) age of mothers was 29.19 (5.75) years; 56.3% of newborns were boys. Geometric mean of urinary BPA and beta-hCG concentrations were 0.36 ng/g crea. (creatinine) and 17736 mIU/ml, respectively. Across the BPA tertiles, the differences in mean values were not significant for none of the anthropometric measurements and gestational age (GA). Furthermore, no significant association existed between unadjusted and adjusted tertiles of BPA and beta-hCG with abovementioned birth outcomes. It seems that the non-significant association found in this study is because of low levels of urinary BPA levels than in other studies; the adverse effects on infants might be related to high concentration of BPA passed from placenta. Future longitudinal studies with large sample size are necessary to document the adverse health effects of maternal exposure to endocrine disruptor chemicals including BPA.

Automated summary

The study aimed to investigate the impact of maternal exposure to BPA on newborn anthropometric measures, but found no significant associations between BPA and beta-hCG concentrations with birth weight, height, and head circumference. The non-significant findings in this study may be due to lower urinary BPA levels, while adverse effects on infants could be related to high concentrations of BPA passed through the placenta. Future longitudinal studies with larger sample sizes are needed to better understand the adverse health effects of endocrine disruptor chemicals like BPA.