A review of environmental occurrence, analysis, bioaccumulation, and toxicity of organophosphate esters

The ban and restriction of polychlorinated biphenyls (PCBs) and major brominated flame retardants (BFRs), including hexabromocyclododecane (HBCD) and polybrominated diphenyl ethers (PBDEs), due to their confirmed detrimental effects on wildlife and humans have paved the way for the wide application of organophosphate esters (OPEs). OPEs have been extensively used as alternative flame retardants, plasticizer, and antifoaming agents in various industrial and consumer products, which leads to an increase in production, usage, and discharge in the environment. We compile recent information on the production/usage and physicochemical properties of OPEs and discussed and compared the available sample treatment and analysis techniques of OPEs, including extraction, clean-up, and instrumental analysis. The occurrence of OPEs in sediment, aquatic biota, surface, and drinking water is documented. Toxicity, human exposure, and ecological risks of OPEs were summarized; toxicological data of several OPEs shows different adverse health effects on aquatic organisms and humans. Much attention was given to document evidence regarding the bioaccumulation and biomagnification potential of OPEs in aquatic organisms. Finally, identified research gaps and avenues for future studies are forwarded.

Automated summary

The prohibition and restriction of PCBs and major BFRs have led to the widespread use of OPEs as alternative chemicals, increasing their production, usage, and discharge into the environment. This study discusses the production/usage, physicochemical properties, and sample treatment techniques of OPEs, as well as their occurrence in various environmental compartments. The toxicity, human exposure, and ecological risks of OPEs are summarized, highlighting their bioaccumulation and biomagnification potential in aquatic organisms.