Journal
BRIEFINGS IN FUNCTIONAL GENOMICS
Volume 15, Issue 2, Pages 155-163Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/elv041
Keywords
yeast; humanization; evolution; functional genomics; high-throughput assays
Funding
- Cancer Prevention and Research Institute of Texas (CPRIT)
- National Institutes of Health
- National Science Foundation
- CPRIT
- Welch foundation [F-1515]
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Despite a billion years of divergent evolution, the baker's yeast Saccharomyces cerevisiae has long proven to be an invaluable model organism for studying human biology. Given its tractability and ease of genetic manipulation, along with extensive genetic conservation with humans, it is perhaps no surprise that researchers have been able to expand its utility by expressing human proteins in yeast, or by humanizing specific yeast amino acids, proteins or even entire pathways. These methods are increasingly being scaled in throughput, further enabling the detailed investigation of human biology and disease-specific variations of human genes in a simplified model organism.
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