Journal
FEBS LETTERS
Volume 590, Issue 18, Pages 3233-3242Publisher
WILEY
DOI: 10.1002/1873-3468.12373
Keywords
brain; farnesoid X receptor; neuron; small heterodimer partner
Funding
- Natural Science Foundation of China [81571323]
- Natural Science Foundation of Jiangsu Province [BK20141240]
- Science and Technology Project of Nantong City [MS12015050]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Farnesoid X receptor (FXR) has been confirmed to sense bile acids in various tissues. However, its expression in brain neurons remains obscure. In this study, we identified FXR mRNA and protein expression in mouse brain neurons and in mouse/human brain tissues. FXR was predominantly localized in the nucleus in cultured neurons, but in neurons in vivo, it mainly appeared in the cytoplasm. In nuclear compartments, the neuronal FXR exhibited a punctate distribution. Activation of FXR increased the small heterodimer partner (SHP) mRNA and protein expression levels in cultured neurons and in brain tissues. These findings will help explore new functions of FXR in the brain.
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