Journal
ENVIRONMENTAL RESEARCH
Volume 204, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2021.112093
Keywords
DNA methylation; Mercury; Methylmercury; Prenatal exposure; PACE; HELIX study; ALSPAC
Funding
- UK Medical Research Council
- Wellcome Trust [102215/2/13/2, WT088806]
- University of Bristol
- UK Biotechnology and Biological Sciences Research Council [BB/I025751/1, BB/I025263/1]
- UK Medical Research Council (MRC) Integrative Epidemiology Unit
- University of Bristol [MC_UU_12013_1, MC_UU_12013_2, MC_UU_12013_5, MC_UU_12013_8]
- United States National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK10324]
- UK MRC Integrative Epidemiology Unit [MC_UU_00011/5]
- Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]
- Spanish Ministry of Health [FIS-PI04/1436, FIS-PI08/1151, FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDERPI03-1615, FIS-FEDER PI16/1288, FIS-FEDER PI19/1338, FEDER 15/0025, 20/0006, FIS-FSE: 17/00260]
- Generalitat de Catalunya-CIRIT [1999SGR 00241]
- Generalitat Valenciana [BEST/2020/059]
- Fundacio La Marato de TV3 [090,430]
- EU Commission [261357MeDALL]
- European Research Council [268479]
- Korean Environment Industry & Technology Institute (KEITI) through the Environmental Health Action Program - Korea Ministry of Environment [2017001360005]
- Norwegian Ministry of Health and Care Services
- NIH/NIEHS [N01-ES-75558]
- NIH/NINDS [1 UO1 NS 047537-01, 2 UO1 NS 047537-06A1]
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01-ES-49019]
- Norwegian Research Council/BIOBANK [221097]
- Ulleval Hospitals Research Council (Oslo University Hospital)
- Unger-Vetlesens foundation
- Norwegian American Womens Club
- INCA/Plan Cancer-EVA-INSERM, France
- International Childhood Cancer Cohort Consortium (I4C)
- INCA/Plan CancerEVA-INSERM (France)
- IARC
- EC
- NIH [R01HL111108, R01NR013945, R37 HD034568]
- Greek Ministry of Health
- MICINN [MTM2015-68140-R]
- Centro Nacional de Genotipado-CEGEN-PRB2ISCIII
- H2020-EU.3.1.2. -Preventing Disease Programme [874583]
- European Union [733206]
- Japanese Ministry of Health, Labour and Welfare [JPMH14427175, JPMH19189425, JPMH17932352]
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology [JP16H02645, JP19H01071, JP18H03035, JP15H04780, JP19K10576, JP19K10636, JP18K10042, JP18K10022, JP19K22730, JP19K20457]
- Environment Research and Technology Development fund [JPMEERF20145054, JPMEERF20175053, JPMEERF20205002]
- AMED [JPMH19188595, JPMH18950314]
- Ministry of Internal Affairs and Communications [JPMI10001]
- Ministry of Education and Research
- Spanish Ministry of Health (FEDER funds)
- MRC [MC_PC_19009] Funding Source: UKRI
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This study found associations between prenatal MeHg exposure and cord blood DNA methylation levels, but limited evidence of these relationships in blood from 7 to 8 year-old children.
Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (beta = 2.28 x 10-4, p-value = 5.87 x 10-5) in relation to prenatal MeHg exposure. In child blood, we identified
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