Journal
ENVIRONMENTAL POLLUTION
Volume 282, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2021.117029
Keywords
Cadmium; Nephrotoxicity; miR-34a; Sirt1; p53
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Funding
- National Science Foundation of China [31972070, 31571836]
- Shandong Agricultural Innovation Team [SDAIT-24-05]
- Major Projects of agricultural application technology innovation in Shandong Prozialeck and Edwards (2012)
- Shandong Double Tops Program [SYT2017XTTD04]
- Incubation Program of Youth Innovation in Shandong Province
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The study found that cadmium can induce renal damage in mice through inflammation and apoptosis via the miR-34a/Sirt1/p53 axis. This is the first report on the role of miR-34a/Sirt1/p53 axis in regulating cadmium-induced apoptosis and nephrotoxicity in mice, providing new insights into miRNA-based regulation of heavy metal induced-nephrotoxicity.
Cadmium (Cd), as an environmental pollutant, can lead to nephrotoxicity. However, its nephrotoxico-logical mechanisms have not been fully elucidated. In this study, Cd (1.5 mg/kg body weight, gavaged for 4 weeks) was found to induce the renal damage in mice, based on indicators including Cd concentration, kidney index, serum creatinine and blood urea nitrogen levels, pro-inflammatory cytokines and their mRNA expressions, levels of Bcl-2, Bax and caspase9, and histopathological changes of the kidneys. Furthermore, Cd-caused detrimental changes through inducing inflammation and apoptosis via the miR-34a/Sirt1/p53 axis. This is the first report on the role of miR-34a/Sirt1/p53 axis in regulating Cd-caused apoptosis and nephrotoxicity in mice. The findings obtained in this study provide new insights into miRNA-based regulation of heavy metal induced-nephrotoxicity. (c) 2021 Elsevier Ltd. All rights reserved.
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