Journal
FEBS LETTERS
Volume 590, Issue 16, Pages 2575-2583Publisher
WILEY-BLACKWELL
DOI: 10.1002/1873-3468.12261
Keywords
amyloid fibril formation; circular dichroism; cyclic beta-hairpins; cytotoxicity inhibition; human pancreatic amylin; thioflavin T fluorescence; type II diabetes
Funding
- National Institutes of Health (NIH) [GM099889]
- Deutsche Forschungsgemeinschaft
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Versions of a previously discovered -hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors. The cyclized hairpin, cyclo-WW2, displays inhibitory activity at substoichiometric concentrations relative to this amyloidogenic peptide. The hairpin-binding hypothesis stands confirmed.
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