Journal
FEBS LETTERS
Volume 590, Issue 7, Pages 908-923Publisher
WILEY
DOI: 10.1002/1873-3468.12087
Keywords
genome regulation; mitochondria; multiple myeloma; nuclear proteostasis; nuclear receptor corepressor 1; ubiquitin-proteasome system
Funding
- National Institute on Aging [K01AG036744]
- Cancer Prevention and Research Institute of Texas [RR140038]
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The recruitment of transcription factors to promoters and enhancers is a critical step in gene regulation. Many of these proteins are quickly removed from DNA after they completed their function. Metabolic genes in particular are dynamically regulated and continuously adjusted to cellular requirements. Transcription factors controlling metabolism are therefore under constant surveillance by the ubiquitin-proteasome system, which can degrade DNA-bound proteins in a site-specific manner. Several of these metabolic transcription factors are critical to cancer cells, as they promote uncontrolled growth and proliferation. This review highlights recent findings in the emerging field of nuclear proteolysis and outlines novel paradigms for cancer treatment, with an emphasis on multiple myeloma.
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