Journal
BRIEFINGS IN BIOINFORMATICS
Volume 17, Issue 1, Pages 117-131Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbv027
Keywords
protein-protein interaction; protein interface prediction; antibody antigen interaction
Funding
- Science Programme (UK Engineering and Physical Sciences Research Council (EPSRC) Cross-Discipline Interface Programme) [EP/I017909/1]
- EPSRC [EP/I017909/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I017909/1] Funding Source: researchfish
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The majority of biological processes are mediated via protein-protein interactions. Determination of residues participating in such interactions improves our understanding of molecular mechanisms and facilitates the development of therapeutics. Experimental approaches to identifying interacting residues, such as mutagenesis, are costly and time-consuming and thus, computational methods for this purpose could streamline conventional pipelines. Here we review the field of computational protein interface prediction. We make a distinction between methods which address proteins in general and those targeted at antibodies, owing to the radically different binding mechanism of antibodies. We organize the multitude of currently available methods hierarchically based on required input and prediction principles to provide an overview of the field.
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