Journal
FEBS LETTERS
Volume 590, Issue 16, Pages 2709-2724Publisher
WILEY
DOI: 10.1002/1873-3468.12309
Keywords
apoptosis; hepatic stellate cells; hepatitis C virus; liver fibrosis; miR-1273g-3p; PTEN
Funding
- Wang Bao-en Foundation of Hepatic Fibrosis
- Chinese Foundation for Hepatitis Prevention and Control [20140018]
- International Science & Technological Foundation of Hebei Province [15397704D]
- Key Science and Technology Project of Hebei Province [14277746D]
- Graduate Student Innovation Fund Project in Hebei Province
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MicroRNA (miRNA) play a pivotal role in the development of liver fibrosis. However, the functions of miRNA in hepatitis C virus (HCV)-related liver fibrosis remain unclear. In this study, we systematically analyzed the microarray data of the serum miRNA in patients with HCV-induced hepatic fibrosis. Among 41 dysregulated miRNA, miR-1273g-3p was the most significantly upregulated miRNA and correlated with the stage of liver fibrosis. Overexpression of miR-1273g-3p could inhibit translation of PTEN, increase the expression of -SMA, Col1A1, and reduce apoptosis in HSCs. Hence, we conclude that miR-1273g-3p might affect the activation and apoptosis of HSCs by directly targeting PTEN in HCV-related liver fibrosis.
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