Journal
FEBS JOURNAL
Volume 283, Issue 13, Pages 2448-2457Publisher
WILEY
DOI: 10.1111/febs.13730
Keywords
core cellular functions; homeostasis; innate immunity; pathogen recognition; protein translation; unfolded protein response
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Funding
- Fundacao da Ciencia e Tecnologia (FCT) [PD/BD/105998/2014]
- European Research Council [ERC-2014-CoG 647888-iPROTECTION]
- Fundação para a Ciência e a Tecnologia [PD/BD/105998/2014] Funding Source: FCT
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Pathogen recognition, signaling transduction pathways, and effector mechanisms are necessary steps of innate immune responses that play key roles in the early phase of defense and in the stimulation of the later specific response of adaptive immunity. Here, we argue that in addition to the direct recognition of conserved common structural and functional molecular signatures of microorganisms using pattern recognition receptors, hosts can mount an immune response following the sensing of disruption in homeostasis as proximal reporters for infections. Surveillance of disruption of core cellular activities leading to defense responses is a flexible strategy that requires few additional components and that can effectively detect relevant threats. It is likely to be evolutionarily very conserved and ancient because it is operational in organisms that lack pattern recognition triggered immunity. A homeostasis disruption model of immune response initiation and modulation has broad implications for pathophysiology and treatment of disease and might constitute an often overlooked but central component of a comprehensive conceptual framework for innate immunity.
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