Journal
ENDOCRINE PRACTICE
Volume 27, Issue 11, Pages 1114-1118Publisher
ELSEVIER INC
DOI: 10.1016/j.eprac.2021.06.014
Keywords
thyroid cancer; thyroglobulin; thyroglobulin antibody; thyroid autoantibodies; autoimmune; Hashimoto's thyroiditis
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This study aimed to evaluate the significance of antithyroglobulin and antithyroid peroxidase antibody levels in patients with well-differentiated thyroid cancer. Results showed that elevated TgAb levels were associated with nodal metastases and ENE, while elevated TPOAb levels were correlated with lower T and N stages.
Objective: To evaluate the significance of antithyroglobulin and antithyroid peroxidase antibody levels associated with locoregional metastatic disease in patients with well-differentiated thyroid cancer. Methods: Patients underwent initial treatment for well-differentiated thyroid cancer at our institution between 2014 and 2018. The following variables were collected: age, sex, pre-operative thyroid -stimulating hormone, thyroglobulin, antithyroglobulin antibody (TgAb), antithyroid peroxidase antibody (TPOAb), the extent of surgery, T-stage, N-stage, extrathyroidal extension (ETE), extranodal extension (ENE), lymphovascular invasion, and multifocal disease. The relationships between disease status and pre-operative TPOAb, TgAb, thyroglobulin, and thyroid-stimulating hormone were analyzed. Results: A total of 405 patients (mean age, 52 years) were included in the study, of which 66.4% were women. Elevated TgAb was associated with the presence of lymph node metastases (LNM) in both the central and lateral neck (P .01), with a stronger correlation to N1b versus N1a disease (P = .03). The presence of ETE was inversely related to the TgAb titer (P = .03). TPOAb was associated with a lower T-stage (P = .04), fewer LNM (P = .04), and a lower likelihood of ETE (P = .02). From multivariable analysis, TgAb .01). TPOAb 60 IU/mL was associated with a lower T-stage (P =.04 for T <3) and absence of ETE (P = .01). Conclusion: Elevated pre-operative TgAb was an independent predictor of nodal metastases and ENE, while elevated TPOAb was associated with a lower pathologic T-and N-stage. Pre-operative antithyroid antibody titers may be useful to inform the disease extent and features. (c) 2021 AACE. Published by Elsevier Inc. All rights reserved.
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