Journal
ENDOCRINE PATHOLOGY
Volume 32, Issue 4, Pages 517-523Publisher
HUMANA PRESS INC
DOI: 10.1007/s12022-021-09681-2
Keywords
Gastric; Neuroendocrine tumour; Type 1; Grade 3; Autoimmune gastritis
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This report describes a patient with aggressive high-grade gastric neuroendocrine tumour, associated with autoimmune gastritis, showing rapid disease progression and poor prognosis. Targeted next-generation sequencing identified pathogenic gene variants contributing to tumor differentiation and metastasis. Liver metastasis was detected during follow-up, and the patient succumbed to disease progression after 6 years.
Gastric type 1 neuroendocrine tumours are considered to have low rates of proliferation and a good prognosis. We report here a patient with an aggressive well-differentiated high-grade gastric neuroendocrine tumour (gastric grade 3 NET), in a context of autoimmune gastritis. Consistent with grade 3 disease, the tumour had a Ki-67 proliferation index of 30%. Targeted next-generation sequencing identified variants of four genes, including a pathogenic ATM variant underlying the differentiation and metastatic potential of the tumour. Liver metastasis was diagnosed during follow-up, and the patient died after 6 years, due to disease progression.
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