Journal
EMBO JOURNAL
Volume 40, Issue 19, Pages -Publisher
WILEY
DOI: 10.15252/embj.2021108863
Keywords
aging; cancer; inflammation; metabolic syndromes; neurodegeneration
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Funding
- MRC [UKDRI-2002] Funding Source: UKRI
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Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
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