Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 215, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2021.112129
Keywords
Avermectin; Cytotoxicity; DNA damage; Programmed cell death; Human A549 cells
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Funding
- Shanghai Sailing Program [19YF1411100]
- Innovation Program of Shanghai Municipal Education Commission [201701070002E00037]
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The study found that Avermectin (AVM) has significant cytotoxic effects on human lung A549 cells, posing a potential threat to human health by inducing DNA damage and programmed cell death.
Avermectin (AVM), as a biological insecticide, is widely used in agriculture and forestry production globally. However, inhalation of AVM may pose a risk, and the lung is the direct target, but the cytotoxicity of AVM on human lung cells is still unclear. Here, we attempted to elucidate the cytotoxic effect and molecular mechanism of AVM on human lung A549 cells. The results indicated that AVM inhibits cell proliferation, and enhances programmed cell death (apoptosis and autophagy). In addition, we found the AVM-treated cells showed an obvious drop in mitochondrial membrane potential and LC3-I/II, increased ROS production, DNA double-strand breaks, caspase-3/9 activated, PARP cleaved, cytochrome c and Bax/Bcl-2 content rise. The results showed that AVM induced mitochondria-related apoptosis and autophagy in lung A549 cells. These results indicate that AVM can pose a potential threat to human health by inducing DNA damage and programmed cell death.
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