Journal
DYES AND PIGMENTS
Volume 190, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.109307
Keywords
ROS; Photodynamic therapy; Redox-responsive; Tumour targeting; Self-assembled nanoparticles
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [2012R1A3A2048814]
- MPO [FV10599, FV30300]
- Czech Academy of Sciences [VAJVA-19-48]
- University of Chemistry and Technology Prague, MOBI traineeship Programme
- National Natural Science Foundation of China [22078066]
- China Scholarship Council (CSC) [201904910820]
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The redox-responsive nanoparticle is designed to produce singlet oxygen and release anticancer drug in response to GSH-triggered disassembly, making it a promising candidate for photodynamic therapy.
The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).
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