Journal
DRUG DISCOVERY TODAY
Volume 26, Issue 8, Pages 1794-1824Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.05.010
Keywords
Liposomes; Active targeting; Internal stimuli; Self-assembly; Targeted drug delivery; Nanocarriers; Enzyme-responsive liposomes; Redox-responsive liposomes; pH-responsive liposomes; Hypoxia-responsive liposomes; Cancer therapy
Categories
Ask authors/readers for more resources
Liposomes are lipidic supramolecular aggregates with the ability to encapsulate and carry molecules of various natures, making them ideal for drug delivery systems. Recent advancements in chemical modifications have led to the development of smart liposome-based drug delivery systems with tunable features and disease-directed capabilities.
Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems for some time because they offer features such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the chemical modification of liposomes has paved the way to the development of smart liposome-based drug delivery systems, which are characterized by even more tunable and disease-directed features. In this review, we highlight the different types of chemical modification introduced to date, with a particular focus on internal stimuli responsive liposomes and prodrug activation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available