Journal
DRUG DISCOVERY TODAY
Volume 26, Issue 11, Pages 2743-2753Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.07.024
Keywords
Drug resistance; Tumor angiogenesis; Vascular normalization; Anti-angiogenesis inhibitors; Multiplex inhibitors
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81602965, 81573285]
- Natural Science Basic Research Plan in Shaanxi Province of China [2020SF-240, 2017JQ8002]
- China Postdoctoral Science Foundation [2016M602837]
- Fundamental Research Funds for the Central Universities [xzy032020003]
- Xi'an Youth Talent Support Program [095920201313]
- Bao'an TCM Development Foundation [2020KJCX-KTYJ-200]
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One major issue in cancer treatment is resistance to chemotherapeutic drugs, often associated with abnormal blood vessels. Jain's vascular normalization theory has been applied effectively to drug-resistant tumor treatment. By using angiogenesis inhibitors, remodeling abnormal vessel structure and function can maximize the efficacy of chemotherapeutic drugs.
A major problem associated with cancer treatment is resistance-prone chemotherapeutic drugs. An increasing number of studies have documented that the occurrence of resistance tends to be associated with abnormal blood vessels. In 2001, Jain proposed the vascular normalization theory, which was recently applied to the drug-resistant treatment of tumors in the clinic. Through the intervention of angiogenesis inhibitors, remodeling the structure and function of abnormal vessels can maximize the efficacy of chemotherapeutic drugs. In this review, we systematically describe the occurrence and progress of tumor angiogenesis, as well as the pathological characteristics of tumor blood vessels. Moreover, druggable targets for vascular normalization and the development of related inhibitors are also outlined.
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