Journal
DRUG DISCOVERY TODAY
Volume 27, Issue 1, Pages 223-233Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.08.005
Keywords
Organoids; Infectious diseases; Infection; Drug screening; Viruses; Bacteria; Protists
Categories
Funding
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-926]
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Organoids are a flexible tool for modeling viral, bacterial, and protist infections. They can provide fast and reliable information on the biology of pathogens and in drug screening, and have become a focus of attention.
Approaches based on animal and two-dimensional (2D) cell culture models cannot ensure reliable results in modeling novel pathogens or in drug testing in the short term; therefore, there is rising interest in platforms such as organoids. To develop a toolbox that can be used successfully to overcome current issues in modeling various infections, it is essential to provide a framework of recent achievements in applying organoids. Organoids have been used to study viruses, bacteria, and protists that cause, for example, respiratory, gastrointestinal, and liver diseases. Their future as models of infection will be associated with improvements in system complexity, including abilities to model tissue structure, a dynamic microenvironment, and coinfection. Teaser. Organoids are a flexible tool for modelling viral, bacterial and protist infections. They can provide fast and reliable information on the biology of pathogens and in drug screening, and thus have become
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