Downregulation of FABP5 Suppresses the Proliferation and Induces the Apoptosis of Gastric Cancer Cells Through the Hippo Signaling Pathway

Fatty acid binding protein 5 (FABP5) has been reported to play an important role in various cancers. We found that high FABP5 expression was associated with poor histological differentiation and vascular invasion. High FABP5 expression indicated a poor prognosis. Downregulation of FABP5 suppressed cell proliferation, cell migration and invasion, and induced cell apoptosis. Bioinformatic analysis revealed that the Hippo signaling pathway was related to FABP5. We found that overexpression of yes-associated protein 1 (YAP1) could partially reverse the effect of FABP5 knockdown on growth and apoptosis. The FABP5 inhibitor SBFI-26 suppressed the proliferation and promoted the apoptosis of gastric cancer (GC) cells and interfered with the Hippo signaling pathway by inhibiting YAP1. Our data suggested that FABP5 might act as a potential target associated with the Hippo signaling pathway for GC treatment.

Automated summary

FABP5 plays a crucial role in various cancers, with high expression associated with poor prognosis. Inhibition of FABP5 suppresses cell proliferation, migration, invasion, and induces apoptosis, and is related to the Hippo signaling pathway. Overexpression of YAP1 can partially reverse the effects of FABP5 knockdown on cell growth and apoptosis. The FABP5 inhibitor SBFI-26 suppresses proliferation, promotes apoptosis in gastric cancer cells, and interferes with the Hippo signaling pathway by inhibiting YAP1.