Journal
DIABETOLOGIA
Volume 64, Issue 11, Pages 2378-2388Publisher
SPRINGER
DOI: 10.1007/s00125-021-05565-6
Keywords
Beta cells; Innate lymphoid cells; Macrophages; Regeneration; Regulatory T cells; Review; Type 1 diabetes
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Funding
- Canadian Institutes of Health Research [HH3-168005, PJT-165943]
- JDRF Canadian Clinical Trials Network [4-SRA-2020-953-A-N]
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Type 1 diabetes is caused by defects in immune self-tolerance, and certain immune cell populations may have the capacity to promote tolerance and support the regeneration of beta cells. Recent research has shown that macrophages, regulatory T cells, and innate lymphoid cells may play dual roles in immune regulation and tissue regeneration in the context of type 1 diabetes.
Type 1 diabetes results from defects in immune self-tolerance that lead to inflammatory infiltrate in pancreatic islets, beta cell dysfunction and T cell-mediated killing of beta cells. Although therapies that broadly inhibit immunity show promise to mitigate autoinflammatory damage caused by effector T cells, these are unlikely to permanently reset tolerance or promote regeneration of the already diminished pool of beta cells. An emerging concept is that certain populations of immune cells may have the capacity to both promote tolerance and support the restoration of beta cells by supporting proliferation, differentiation and/or regeneration. Here we will highlight three immune cell types-macrophages, regulatory T cells and innate lymphoid cells-for which there is evidence of dual roles of immune regulation and tissue regeneration. We explore how findings in this area from other fields might be extrapolated to type 1 diabetes and highlight recent discoveries in the context of type 1 diabetes. We also discuss technological advances that are supporting this area of research and contextualise new therapeutic avenues to consider for type 1 diabetes.
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