Pre-admission glucagon-like peptide-1 receptor agonist (GLP-1RA) and mortality from coronavirus disease 2019 (Covid-19): A systematic review, meta-analysis, and meta-regression

Review Endocrinology & Metabolism

Diabetes increases the mortality of patients with COVID-19: a meta-analysis

Zeng-hong Wu et al.

Summary: This meta-analysis revealed a significant correlation between diabetes and mortality of COVID-19 patients. The results suggest that blood glucose disturbance in COVID-19 patients may contribute to worsened outcomes.

ACTA DIABETOLOGICA (2021)

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Article Cardiac & Cardiovascular Systems

Are diabetes and its medications risk factors for the development of COVID-19? Data from a population-based study in Sicily

G. Antonio Silverii et al.

Summary: The study conducted in Sicily showed that diabetes mellitus is not a risk factor for COVID-19 infection, but is associated with a higher case fatality rate.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Article Endocrinology & Metabolism

COVID-19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission

Harald Sourij et al.

Summary: This study aimed to assess predictors of in-hospital mortality in people with prediabetes and diabetes hospitalized for COVID-19 infection, finding that the in-hospital mortality rate was higher in people with diabetes compared to those with prediabetes but without statistical significance. A risk score using five routinely available patient variables, including age, arterial occlusive disease, C-reactive protein, estimated glomerular filtration rate, and aspartate aminotransferase levels, showed excellent predictive performance for assessing in-hospital mortality.

DIABETES OBESITY & METABOLISM (2021)

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Article Virology

Tocilizumab administration is associated with the reduction in biomarkers of coronavirus disease 2019 infection

Timotius Ivan Hariyanto et al.

Summary: Meta-analysis study suggests that tocilizumab treatment is effective in reducing the biomarkers of COVID-19 infection.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Endocrinology & Metabolism

Adverse outcomes in COVID-19 and diabetes: a retrospective cohort study from three London teaching hospitals

Chioma Izzi-Engbeaya et al.

Summary: Patients with diabetes mellitus admitted to hospital with COVID-19 have poorer outcomes, with factors such as male gender, advancing age, lower platelet count, and higher Clinical Frailty Scale (CFS) score independently predicting poor outcomes. Antiplatelet medication was associated with a lower risk of death/ICU admission. Comorbidities such as diabetes with ischemic heart disease were major determinants of poor outcomes in COVID-19 patients.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

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Article Endocrinology & Metabolism

Comparable COVID-19 outcomes with current use of GLP-1 receptor agonists, DPP-4 inhibitors or SGLT-2 inhibitors among patients with diabetes who tested positive for SARS-CoV-2

Simone Bastrup Israelsen et al.

Summary: This population-based cohort study found that the use of incretin-based therapies, GLP-1 RAs and DPP-4i, in individuals with diabetes and SARS-CoV-2 infection did not result in improved clinical outcomes compared to SGLT-2i.

DIABETES OBESITY & METABOLISM (2021)

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Article Endocrinology & Metabolism

Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

Matthieu Wargny et al.

Summary: The study identified prognostic factors for hospital discharge and death in patients with diabetes hospitalized for COVID-19, finding that younger age, routine metformin therapy, longer symptom duration on admission were positively associated with discharge, while history of microvascular complications, anticoagulant routine therapy, dyspnoea on admission, and higher levels of certain biomarkers were associated with reduced chance of discharge.

DIABETOLOGIA (2021)

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Review Cardiac & Cardiovascular Systems

Statin and outcomes of coronavirus disease 2019 (COVID-19): A systematic review, meta-analysis, and meta-regression

Timotius Hariyanto et al.

Summary: The study aimed to analyze the association between statin use and composite poor outcomes of COVID-19, and found that statin use did not improve the composite poor outcomes of COVID-19. Age, gender, and cardiovascular disease influenced the association with composite poor outcomes of COVID-19.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Review Pharmacology & Pharmacy

Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Timotius Ivan Hariyanto et al.

Summary: This study suggests that the use of colchicine is associated with improved outcomes of COVID-19, including reduction in severe cases and mortality rate. However, further randomized clinical trial studies are needed to confirm these results.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2021)

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Review Clinical Neurology

Parkinson's disease may worsen outcomes from coronavirus disease 2019 (COVID-19) pneumonia in hospitalized patients: A systematic review, meta-analysis, and meta-regression

Cynthia Putri et al.

Summary: The meta-analysis revealed a significant association between Parkinson's Disease and in-hospital outcomes of COVID-19, with PD patients at higher risk of severe illness and mortality. Age was identified as a factor influencing this association. Careful monitoring and preventive measures are recommended for PD patients to minimize the risks of infections.

PARKINSONISM & RELATED DISORDERS (2021)

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Review Infectious Diseases

Human immunodeficiency virus and mortality from coronavirus disease 2019: A systematic review and meta-analysis

Timotius Hariyanto et al.

Summary: In this meta-analysis, a total of 28 studies with 18,255,040 COVID-19 patients were assessed. Overall, HIV was associated with a higher mortality from COVID-19. Studies from Africa and the United States showed statistically significant associations. The findings suggest that PLWH should be prioritized for receiving the COVID-19 vaccine to minimize the risk of death.

SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE (2021)

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Review Clinical Neurology

Obstructive sleep apnea (OSA) and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: a systematic review and meta-analysis

Timotius Ivan Hariyanto et al.

Summary: This study analyzed the relationship between OSA and poor outcomes of COVID-19, finding that OSA is associated with adverse outcomes and suggesting extra care and close monitoring for OSA patients.

SLEEP MEDICINE (2021)

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Article Endocrinology & Metabolism

Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: A retrospective study from an academic center in Belgium

Laura Orioli et al.

Summary: This study described the characteristics and short-term prognosis of in-patients with diabetes and COVID-19 at a Belgian academic care center. The majority of patients had type 2 diabetes, hyperglycemia-related vascular complications, and hypertension. The overall case-fatality rate was 15%, with no statistically significant difference between patients with and without diabetes.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Review Chemistry, Medicinal

Efficacy and Safety of Tocilizumab for Coronavirus Disease 2019 (Covid-19) Patients: A Systematic Review and Meta-analysis

Timotius Ivan Hariyanto et al.

Summary: The study found that tocilizumab can reduce the mortality rate of COVID-19 patients, but does not affect the severity of the disease and length of hospital stay. Additionally, it is not associated with more serious adverse events compared to standard care treatment. Future research should focus on other potential therapies for COVID-19 patients.

DRUG RESEARCH (2021)

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Review Endocrinology & Metabolism

Glucagon-like peptide-1 receptor agonists in the era of COVID-19: Friend or foe?

Andrej Belancic et al.

Summary: GLP-1RAs, in addition to their role as glucose-lowering agents, also exhibit anti-inflammatory, anti-obesogenic, pulmonary protective, and positive effects on gut microbiome. Hence, they appear to be potential candidates for treating patients affected by COVID-19, with or without type 2 diabetes, and as excellent agents for managing diabetes during the pandemic.

CLINICAL OBESITY (2021)

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Review Endocrinology & Metabolism

COVID-19 and diabetes mellitus: from pathophysiology to clinical management

Soo Lim et al.

Summary: Initial studies have shown that patients with diabetes mellitus have a higher risk of severe COVID-19, potentially due to hyperglycaemia affecting immune and inflammatory responses. Further investigation is needed to determine the optimal management for patients with diabetes mellitus during the ongoing pandemic.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

Bertrand Cariou et al.

DIABETOLOGIA (2020)

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Review Endocrinology & Metabolism

Coronavirus Infections and Type 2 Diabetes-Shared Pathways with Therapeutic Implications

Daniel J. Drucker

ENDOCRINE REVIEWS (2020)

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Article Environmental Sciences

Potential Benefits and Harms of Novel Antidiabetic Drugs during COVID-19 Crisis

Maria Mirabelli et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Letter Pharmacology & Pharmacy

Letter to the editor: Comment on GLP-1-based drugs and COVID-19 treatment

Tianru Jin et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Cell Biology

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Ana Campos Codo et al.

CELL METABOLISM (2020)

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Editorial Material Endocrinology & Metabolism

Practical recommendations for the management of diabetes in patients with COVID-19

Stefan R. Bornstein et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

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Article Endocrinology & Metabolism

ACE2 and SARS-CoV-2 Infection: Might GLP-1 Receptor Agonists Play a Role?

Vincenzo M. Monda et al.

DIABETES THERAPY (2020)

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Review Endocrinology & Metabolism

Diabetes, infection risk and COVID-19

Suheda Erener

MOLECULAR METABOLISM (2020)

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Review Endocrinology & Metabolism

Obesity in patients with COVID-19: a systematic review and meta-analysis

Yi Huang et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

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Article Endocrinology & Metabolism

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection

Timotius Ivan Hariyanto et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Article Medicine, Research & Experimental

Semaglutide lowers body weight in rodents via distributed neural pathways

Sanaz Gabery et al.

JCI INSIGHT (2020)

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Article Cardiac & Cardiovascular Systems

Long-term observational study on the impact of GLP-1R agonists on lung function in diabetic patients

Paola Rogliani et al.

RESPIRATORY MEDICINE (2019)

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Review Endocrinology & Metabolism

A review of GLP-1 receptor agonists: Evolution and advancement, through the lens of randomised controlled trials

Vanita R. Aroda

DIABETES OBESITY & METABOLISM (2018)

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Article Endocrinology & Metabolism

A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota

Li Zhao et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Article Endocrinology & Metabolism

Effect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial

A. Blackman et al.

INTERNATIONAL JOURNAL OF OBESITY (2016)

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Review Cell Biology

Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control

Young-Sun Lee et al.

MEDIATORS OF INFLAMMATION (2016)

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Article Endocrinology & Metabolism

Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats

Marina Romani-Perez et al.

ENDOCRINOLOGY (2015)

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Article Biochemistry & Molecular Biology

Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice

Tao Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Medicine, General & Internal

Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes The SCALE Diabetes Randomized Clinical Trial

Melanie J. Davies et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

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Article Medicine, General & Internal

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

Xavier Pi-Sunyer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Review Public, Environmental & Occupational Health

Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: the Newcastle-Ottawa Scale and the RTI item bank

Andrea V. Margulis et al.

CLINICAL EPIDEMIOLOGY (2014)

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Article Pharmacology & Pharmacy

GLP-1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats

Hui-Chun Ku et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2010)

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Review Genetics & Heredity

Lessons from SARS: control of acute lung failure by the SARS receptor ACE2

Keiji Kuba et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2006)

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Article Cardiac & Cardiovascular Systems

The metabolic syndrome: Inflammation, diabetes mellitus, and cardiovascular disease

SM Haffner

AMERICAN JOURNAL OF CARDIOLOGY (2006)

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Pre-admission glucagon-like peptide-1 receptor agonist (GLP-1RA) and mortality from coronavirus disease 2019 (Covid-19): A systematic review, meta-analysis, and meta-regression

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