Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 122, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2021.104113
Keywords
microRNA; IL-1 beta; Negative regulation; Innate immune; Fish
Categories
Funding
- National Natural Science Foundation of China [31802325]
- National Key Research and Development Project [2018YFD0900301]
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The innate immune system is the first line of defense against pathogens, while microRNA miR-132 plays a crucial role in regulating immune responses, specifically by targeting IL-1 beta to prevent excessive inflammation.
The innate immune system is the first line of defense against the invasion of pathogens. It can make a rapid immune response to the invading pathogenic microorganisms, thereby eliminating the invading pathogens and protecting the body from harm. microRNAs are a family of small non-coding ribonucleic acid molecules, which are important and multifunctional regulator of immune response. In this study, we studied the role of miR-132 as a key regulatory factor of IL-1 beta-mediated inflammation. The seed region of miR-132 can regulate gene expression by binding to the 3'UTR of if -1 beta, and inhibit the expression of IL-1 beta at the post-transcriptional level. More importantly, miR-132 inhibits LPS-induced NF-kappa B signaling pathway by targeting if -1 beta, thereby preventing excessive inflammatory response from causing autoimmune diseases. These results will help to better understand the complex regulatory mechanisms of teleost fishes.
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