TEAD family transcription factors in development and disease

The balance between stem cell potency and lineage specification entails the integration of both extrinsic and intrinsic cues, which ultimately influence gene expression through the activity of transcription factors. One example of this is provided by the Hippo signalling pathway, which plays a central role in regulating organ size during development. Hippo pathway activity is mediated by the transcriptional co-factors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which interact with TEA domain (TEAD) proteins to regulate gene expression. Although the roles of YAP and TAZ have been intensively studied, the roles played by TEAD proteins are less well understood. Recent studies have begun to address this, revealing that TEADs regulate the balance between progenitor self-renewal and differentiation throughout various stages of development. Furthermore, it is becoming apparent that TEAD proteins interact with other co-factors that influence stem cell biology. This Primer provides an overview of the role of TEAD proteins during development, focusing on their role in Hippo signalling as well as within other developmental, homeostatic and disease contexts.

Automated summary

The balance between stem cell potency and lineage specification relies on the integration of extrinsic and intrinsic cues to influence gene expression through transcription factors. The Hippo signalling pathway, particularly involving YAP, TAZ, and TEAD proteins, plays a key role in regulating organ size and progenitor self-renewal during development. Studies are revealing the intricate roles of TEAD proteins in maintaining the balance between stem cell self-renewal and differentiation in various developmental stages.