4.7 Review

Advances in live imaging early mouse development: exploring the researcher's interdisciplinary toolkit

Journal

DEVELOPMENT
Volume 148, Issue 18, Pages -

Publisher

COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.199433

Keywords

Image analysis; Imaging developmental processes; Microscopy; Mouse embryology

Funding

  1. Wellcome Trust [103788/Z/14/Z]

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Live imaging plays a crucial role in studying early mouse embryogenesis by enabling researchers to visualize and intervene in dynamic events during development. Advances in embryo culture, microscopy hardware, and computational analysis have contributed to the development of a versatile toolkit for live imaging studies.
Live imaging is an important part of the developmental biologist's armoury of methods. In the case of the mouse embryo, recent advances in several disciplines including embryo culture, microscopy hardware and computational analysis have all contributed to our ability to probe dynamic events during early development. Together, these advances have provided us with a versatile and powerful 'toolkit', enabling us not only to image events during mouse embryogenesis, but also to intervene with them. In this short Spotlight article, we summarise advances and challenges in using live imaging specifically for understanding early mouse embryogenesis.

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