Journal
CYTOSKELETON
Volume 78, Issue 6, Pages 303-311Publisher
WILEY
DOI: 10.1002/cm.21677
Keywords
actin cytoskeleton; focal adhesions; LIM proteins; adherens junctions
Categories
Funding
- National Institute of General Medical Sciences [RO1 GM104032]
- National Science Foundation [DMR-2011854, DMR-1420709]
- National Institutes of Health MCB Training [T32 GM0071832]
- Army Research Office [W911NF1410403]
- National Institutes of Health [F32 GM122372, R01 GM079265]
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This review summarizes the role of LIM proteins in mechanical sensing, highlighting their binding to mechanically stressed actin filaments as a novel and widely conserved mechanism of mechanosensing.
The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.
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