4.6 Review

The cytokine interleukin-11 crucially links bone formation, remodeling and resorption

Journal

CYTOKINE & GROWTH FACTOR REVIEWS
Volume 60, Issue -, Pages 18-27

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2021.04.002

Keywords

Interleukin-11; Interleukin-11 receptor; gp130; Osteoblast; Osteoclast; Bone

Funding

  1. Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [125440785 - SFB 877]

Ask authors/readers for more resources

Bone development requires the coordinated action of different signaling pathways and cell types, with IL-11 playing a crucial regulatory role. Missense mutations in the IL11RA gene encoding IL-11R have been linked to craniosynostosis.
Bone development is a complex process that requires the activity of several different signaling pathways and cell types. It involves the coordinated action of osteoclasts (cells that are capable of resorbing bone), osteoblasts (cells that are able to form bone), osteocytes (cells that form a syncytial network within the bone), skeletal muscle cells and the bone marrow. In recent years, the cytokine interleukin-11 (IL-11), a member of the IL-6 family of cytokines, has emerged as an important regulatory protein for bone formation, remodeling and resorption. Furthermore, coding missense mutations in the IL11RA gene, which encodes the IL-11 receptor (IL-11R), have recently been linked to craniosynostosis, a human disease in which the sutures that line the head bones close prematurely. This review summarizes current knowledge about IL-11 and highlights its role in bone development and homeostasis. It further discusses the specificity and redundancy provided by the other members of the IL-6 cytokine family and how they facilitate signaling and cross-talk between skeletal muscle cells, bone cells and the bone marrow. We describe their actions in physiological and in pathological states and discuss how this knowledge could be translated into therapy.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available