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Dibenzofurans from Lichens - A Pharmacological Overview

Journal

CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 21, Issue 26, Pages 2397-2408

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026621666210728095214

Keywords

Dibenzofurans; Lichens; Pharmacology; Activities; Secondary metabolites; Orsellinic acid

Funding

  1. Spanish Ministry of Science, Innovation and Universities [PID2019-105312G-B-100]
  2. Santander-University Complutense of Madrid [PR87/19-22637]
  3. Complutense University of Madrid [CT42/18-CT43/18]

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Lichens are a symbiotic association between a fungus and a green algae/cyanobacterium, with dibenzofurans from lichens showing antibacterial, antifungal, and cytotoxic activities. In the past decade, there has been increasing interest in the pharmacological activity of dibenzofurans, providing future research directions.
Lichens are a symbiotic association between a fungus (mycobiont) and a green algae/cyanobacterium (photobiont). Lichens are a source of secondary metabolites, most of them being exclusively for these species, among which dibenzofurans are found. Dibenzofurans are a small group (over 35 different identified compounds), being usnic acid the most studied. In the last 10 years, there has been a growing interest in the pharmacological activity of dibenzofurans. In this work, dibenzofurans isolated from lichens (alectosarmentin, condidymic acid, didymic acid, isousnic acid, isostrepsilic acid, usimines A-C and usnic acid) were reviewed, most of which showed antibacterial, antifungal, and cytotoxic activities. These findings provide future guidance for research on pharmacological activity of dibenzofurans.

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