4.5 Review

Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues

Journal

CURRENT PHARMACEUTICAL DESIGN
Volume 27, Issue 46, Pages 4686-4692

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612827666210701145438

Keywords

NAFLD; AMPK; VA; hepatic injury; inflamation; fatty liver

Funding

  1. Drug Applied Research Center of Tabriz University of Medical Sciences

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Non-alcoholic fatty liver disease (NAFLD) is a growing health issue globally, characterized by the presence of steatosis in the liver. Vanillic acid (VA), as an anti-inflammatory and anti-oxidative factor, has protective effects on the liver in animal models by reducing liver damage and adipogenesis through AMPK activation, targeting various metabolic abnormalities of NAFLD.
Non-alcoholic fatty liver disease (NAFLD), a growing health issue around the world, is defined as the presence of steatosis in the liver without any other detectable byproducts such as alcohol consumption, which includes a wide spectrum of pathologies, such as steatohepatitis, cirrhosis, and hepatocellular carcinoma. A growing body of evidence indicates that the reduction in the 5' adenosine monophosphate-activated protein kinase (AMPK) activity, which could be activated by the consumption of the drugs, hormones, cytokines, and dietary restriction, is related to some metabolic disorders such as obesity, diabetes, PCOS, and NAFLD. Vanil-lic acid (VA), as an anti-inflammatory, anti-oxidative, anti-angiogenic and anti-metastatic factor, has protective effects on the liver as in two animal models of liver damage, it reduces serum levels of transaminases, inflam-matory cytokines, and the accumulation of collagen in the liver and also prevents liver fibrosis. Besides, it de-creases body and adipose tissue weight in a mice model of obesity and, similar to the liver tissue, diminishes adipogenesis through the activation of AMPK. It has been reported that VA can target almost all of the meta-bolic abnormalities of NAFLD, such as hepatic steatosis, inflammation, and hepatic injury, at least partially through the activation of AMPK. Therefore, in this review, we will discuss the possible and hypothetical roles of VA in NAFLD, with a special focus on AMPK.

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