Journal
CURRENT ORGANIC CHEMISTRY
Volume 25, Issue 15, Pages 1783-1822Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272825666210608114300
Keywords
Toluene; C-H activation; C-C coupling; C-heteroatom bond formation; cross dehydrogenative coupling; directing groups
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Funding
- VIT, Vellore
- VIT
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This review provides an overview of the synthetic utility of toluene and its derivatives, exploring the use of both alkyl-sp(3) and aryl-sp(2) carbons through C-H activation. The review also discusses the impact of different substituents on toluene derivatives in facilitating various reactions.
Toluene and its derivatives have been well established as versatile scaffolds in organic synthesis over the last few decades. This review provides a brief and concise overview of the current status and latest methodologies in the synthetic utility of toluene and its derivatives by exploiting both the alkyl-sp(3) and aryl-sp(2) carbons via C-H activation. The review also explores the effect of various substituents on the toluene derivatives in facilitating different reactions.
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