Journal
CURRENT ORGANIC CHEMISTRY
Volume 25, Issue 18, Pages 2142-2154Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272825666210728101823
Keywords
Coumarins; fluorescent probe; mechanism; metal; bioimaging; cells
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Coumarin-based derivatives have versatile properties and have been widely used in various applications, especially in biosensing. This review focuses on recent advances of coumarin-based fluorescent probes for metal ion imaging in living cells, highlighting representative examples and fluorescence response mechanisms such as PET, ICT, and FRET. Future perspectives in this field are also briefly mentioned.
Coumarin-based derivatives have easy modification and tunable properties and have been synthesized and applied in many areas including pro-drugs, biomedical materials, and chemical and biological sensing. In this review, recent advances of coumarin-based fluorescent probes for biosensing are reported for metal ion imaging. Metal detection in living cells are highlighted with representative examples together with fluorescence response mechanisms such as Photoinduced Electron Transfer (PET), Intramolecular Charge Transfer (ICT), and Fluorescence Resonance Energy Transfer (FRET). Some future perspectives are also briefly mentioned.
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