Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 68, Issue -, Pages 122-128Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2021.01.002
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Funding
- NIGMS [DP2GM128201]
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Outer membrane proteins have a consistent structure, composed of repeated I3-hairpins, which allows for the investigation of the evolution of these repetitive structures. Research into outer membrane protein evolution can be used for designing novel outer membrane proteins.
Outer membrane proteins have remarkably homogeneous structure. They are all up down I3-barrels. Up down barrels themselves are composed of repeated sets of I3-hairpins. The consistency of the usage of the I3-hairpin throughout the outer membrane milieu allows for interrogation of the evolution of these repetitive structures. Here we describe recent investigations of outer membrane protein evolution and how evolutionary precepts have been used for novel outer membrane protein design.
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