Cell adhesion molecules regulating astrocyte-neuron interactions

A tripartite synapse comprises a neuronal presynaptic axon and a postsynaptic dendrite, which are closely ensheathed by a perisynaptic astrocyte process. Through their structural and functional association with thousands of neuronal synapses, astrocytes regulate synapse formation and function. Recent work revealed a diverse range of cell adhesion-based mechanisms that mediate astrocyte-synapse interactions at tripartite synapses. Here, we will review some of these findings unveiling a highly dynamic bidirectional signaling between astrocytes and synapses, which orchestrates astrocyte morphological maturation and synapse development. Moreover, we will discuss the roles of these newly discovered molecular pathways in brain physiology and function both in health and disease.

Automated summary

Astrocytes play a key role in regulating synapse formation and function by interacting with neuronal synapses at tripartite synapses. Recent studies have shown a diverse range of cell adhesion-based mechanisms that mediate astrocyte-synapse interactions and influence both astrocyte morphological maturation and synapse development. These newly discovered molecular pathways in brain physiology have implications for both health and disease.