Related references
Note: Only part of the references are listed.The role of glutaminase in cancer
Brendah K. Masisi et al.
HISTOPATHOLOGY (2020)
N-acetylaspartylglutamate (NAAG) and glutamate carboxypeptidase II: An abundant peptide neurotransmitter-enzyme system with multiple clinical applications
Joseph H. Neale et al.
PROGRESS IN NEUROBIOLOGY (2020)
Metabolic Reprogramming in Triple-Negative Breast Cancer
Sun Xiangyu et al.
FRONTIERS IN ONCOLOGY (2020)
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker
Bridget Duvall et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers
Yao-An Shen et al.
CANCER RESEARCH (2020)
Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer
Allison S. Cohen et al.
TRANSLATIONAL ONCOLOGY (2020)
Glutaminase 2 functions as a tumor suppressor gene in gastric cancer
Liang Xu et al.
TRANSLATIONAL CANCER RESEARCH (2020)
Tumor-Targeted Delivery of 6-Diazo-5-oxo-L-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs
Lukas Tenora et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization
Lisha Xiang et al.
CELL DEATH & DISEASE (2019)
Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer
Tu Nguyen et al.
CELL REPORTS (2019)
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
Robert D. Leone et al.
SCIENCE (2019)
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
Michael J. Lukey et al.
CELL REPORTS (2019)
Glutamine Addiction and Therapeutic Strategies in Lung Cancer
Karolien Vanhove et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
The Metabolic Interplay between Cancer and Other Diseases
Anne Le et al.
TRENDS IN CANCER (2019)
Automated synthesis of [11C]L-glutamine on Synthra HCN plus synthesis module
Prashanth K. Padakanti et al.
EJNMMI RADIOPHARMACY AND CHEMISTRY (2019)
Amino Acid Transporters and Glutamine Metabolism in Breast Cancer
Yoon Jin Cha et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
Michael L. Schulte et al.
NATURE MEDICINE (2018)
Glutaminase isoenzymes in the metabolic therapy of cancer
Jose M. Mates et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)
We're Not DON Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine
Kathryn M. Lemberg et al.
MOLECULAR CANCER THERAPEUTICS (2018)
A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis
William P. Katt et al.
FUTURE MEDICINAL CHEMISTRY (2017)
A Functional Mammalian Target of Rapamycin Complex 1 Signaling Is Indispensable for c-Myc-Driven Hepatocarcinogenesis
Pin Liu et al.
HEPATOLOGY (2017)
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers
Arimichi Okazaki et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells
Robin M. Meyers et al.
NATURE GENETICS (2017)
Glutamine Addiction In Gliomas
Javier Marquez et al.
NEUROCHEMICAL RESEARCH (2017)
Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells
Ravyn M. Thompson et al.
ONCOTARGET (2017)
Combination therapy in combating cancer
Reza Bayat Mokhtari et al.
ONCOTARGET (2017)
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
Milica Momcilovic et al.
CELL REPORTS (2017)
Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging
Omran Abu Aboud et al.
CANCER RESEARCH (2017)
Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors
Stephan Bernhardt et al.
BREAST CANCER RESEARCH (2017)
GPNA inhibits the sodium-independent transport system L for neutral amino acids
Martina Chiu et al.
AMINO ACIDS (2017)
Glutamine transporters in mammalian cells and their functions in physiology and cancer
Yangzom D. Bhutia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
Marina Bolzoni et al.
BLOOD (2016)
Discovery of 6-Diazo-5-oxo-L-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma
Rana Rais et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer
Amira Elgogary et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold
Sarah C. Zimmermann et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Structural basis for exploring the allosteric inhibition of human kidney type glutaminase
Sarath Ramachandran et al.
ONCOTARGET (2016)
Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis
Cen Zhang et al.
ELIFE (2016)
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
Nathalie Jacque et al.
BLOOD (2015)
Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies
Young Joo Jeon et al.
CANCER CELL (2015)
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Yan Xiang et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Dysregulated metabolism contributes to oncogenesis
Matthew D. Hirschey et al.
SEMINARS IN CANCER BIOLOGY (2015)
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells
Clint A. Stalnecker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer
K. Shimizu et al.
BRITISH JOURNAL OF CANCER (2014)
Altered Glutamine Metabolism and Therapeutic Opportunities for Lung Cancer
Amr Mohamed et al.
CLINICAL LUNG CANCER (2014)
Metformin, cancer and glucose metabolism
Barbara Salani et al.
ENDOCRINE-RELATED CANCER (2014)
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
Matt I. Gross et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Lifeng Yang et al.
MOLECULAR SYSTEMS BIOLOGY (2014)
Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter
Anne Lea et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
Sarah-Maria Fendt et al.
CANCER RESEARCH (2013)
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
Jing Fan et al.
MOLECULAR SYSTEMS BIOLOGY (2013)
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Jaekyoung Son et al.
NATURE (2013)
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
Anne Le et al.
CELL METABOLISM (2012)
Glutaminolysis Activates Rag-mTORC1 Signaling
Raul V. Duran et al.
MOLECULAR CELL (2012)
Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor
Byron DeLaBarre et al.
BIOCHEMISTRY (2011)
Therapeutic targeting of cancer cell metabolism
Chi V. Dang et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2011)
Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
Jian-Bin Wang et al.
CANCER CELL (2010)
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
Sawako Suzuki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
Wenwei Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Glutamine addiction: a new therapeutic target in cancer
David R. Wise et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Paul Nicklin et al.
CELL (2009)
MYC, microRNAs and glutamine addiction in cancers
Chi V. Dang
CELL CYCLE (2009)
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
Chi V. Dang et al.
CLINICAL CANCER RESEARCH (2009)
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
NATURE (2009)
Crystal structures of Escherichia coli γ-glutamyltranspeptidase in complex with azaserine and acivicin:: Novel mechanistic implication for inhibition by glutamine antagonists
Kei Wada et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
Mary M. Robinson et al.
BIOCHEMICAL JOURNAL (2007)
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
Mariia Yuneva et al.
JOURNAL OF CELL BIOLOGY (2007)
Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site
CS Esslinger et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Mechanism for acivicin inactivation of triad glutamine amidotransferases
SV Chittur et al.
BIOCHEMISTRY (2001)
Share Paper
