Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 63, Issue -, Pages 11-18Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2021.01.011
Keywords
Metabolism; Chromatin; Epigenetics; Transcription; Methionine
Categories
Funding
- National Institutes of Health [R01CA193256]
- American Cancer Society [RSG-16-214-01-TBE]
Ask authors/readers for more resources
Chromatin and associated epigenetic marks provide important platforms for gene regulation in response to metabolic changes associated with environmental exposures. Studies have shown that fluctuations of key metabolites can influence chromatin modifications, but their effects on chromatin structure are largely unknown.
Chromatin and associated epigenetic marks provide important platforms for gene regulation in response to metabolic changes associated with environmental exposures, including physiological stress, nutritional deprivation, and starvation. Numerous studies have shown that fluctuations of key metabolites can influence chromatin modifications, but their effects on chromatin structure (e.g. chromatin compaction, nucleosome arrangement, and chromatin loops) and how they appropriately deposit specific chemical modification on chromatin are largely unknown. Here, focusing on methionine metabolism, we discuss recent developments of metabolic effects on chromatin modifications and structure, as well as consequences on gene regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available