Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 71, Issue -, Pages 103-111Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2021.02.009
Keywords
Membrane curvature; Multiscale simulations; Organelle shape; Mesoscale models; Molecular dynamics; Cell membranes
Categories
Funding
- Netherlands Ministry of Education, Culture, and Science (OCW) [024.003.019]
- Netherlands Organization for Scientific Research (NWO)
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Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. Simulation studies using a diverse range of computational techniques are able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Recent advances highlight the understanding of this complexity, identify current bottlenecks, and sketch possible ways ahead.
Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.
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