Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 69, Issue -, Pages 112-117Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2020.12.014
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Funding
- National Science Foundation [IOS-1655438]
- USDA National Institute of Food and Agriculture [2020-67013-30885]
- USDA National Institute of Food and Agriculture Hatch Project [177845]
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This article discusses the obstacles in the production of plant chemicals, including substrate availability, silent metabolism, and metabolic crosstalk, and proposes strategies to overcome these limitations.
Metabolic engineering is embraced as a method to sustainably enhance production of valuable phytochemicals with beneficial properties. However, successful production of these compounds in plants is not always predictable even when the pathways are fully known, frequently due to the lack of comprehensive understanding of plant metabolism as a whole, and interconnections between different primary, secondary, and hormone metabolic networks. Here, we highlight critical hidden constraints, including substrate availability, silent metabolism, and metabolic crosstalk, that impair engineering strategies. We explore how these constraints have historically been manifested in engineering attempts and propose how modern advancements will enable future strategies to overcome these impediments.
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