Cell-adhesion Molecules as Key Mechanisms of Tumor Invasion: The Case of Breast Cancer

Cancer is a major health problem worldwide and the second leading cause of death following cardiovascular diseases. Breast cancer is the leading cause of mortality and morbidity among women and one of the most common malignant neoplasms prompt to metastatic disease. In the present review, the mechanisms of the major cell adhesion molecules involved in tumor invasion are discussed, focusing on the case of breast cancer. A non-systematic updated revision of the literature was performed in order to assemble information regarding the expression of the adhesion cell molecules associated with metastasis.

Automated summary

Cancer, particularly breast cancer, is a significant global health issue associated with high mortality and morbidity rates. This review focuses on the mechanisms of cell adhesion molecules in tumor invasion, specifically in breast cancer, by conducting an updated literature review on the expression of these molecules associated with metastasis.