4.4 Review

Combating the Progression of Novel Coronavirus SARS-CoV-2 Infectious Disease: Current State and Future Prospects in Molecular Diagnostics and Drug Discovery

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

COVID-19 and ARDS: Update on Preventive and Therapeutic Venues

Arun Narota et al.

Summary: The novel coronavirus SARS-CoV-2, which originated in China, has become a global concern impacting the health, economic, and political conditions of nations worldwide. Scientists are working to understand the disease and develop strategies, including therapeutics and vaccines, to combat COVID-19. Prevention measures and widespread testing are being implemented globally to curb transmission.

CURRENT MOLECULAR MEDICINE (2022)

Review Immunology

A systematic review of asymptomatic infections with COVID-19

Zhiru Gao et al.

Summary: Since the outbreak of COVID-19 at the end of December 2019, it has caused significant harm and challenges to over 200 countries and regions worldwide. Many patients with COVID-19 are asymptomatic or have only mild symptoms, yet they can still spread the virus, making screening for asymptomatic infections difficult and complicating national prevention and control efforts.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2021)

Article Biochemistry & Molecular Biology

Chloroquine and hydroxychloroquine in the prophylaxis and therapy of COVID-19 infection

Ernesto Carafoli

Summary: The passage discusses the controversy surrounding chloroquine and hydroxychloroquine in COVID-19 infection, noting that opinions on these drugs are often influenced by non-scientific opinions and political factors.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Review Infectious Diseases

Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis

Zakariya Kashour et al.

Summary: The study included 7 RCTs and 14 cohort studies with a total of 20979 patients. Results indicated that HCQ lacks efficacy in reducing short-term mortality in COVID-19 hospitalized patients and the risk of hospitalization in outpatients. Additionally, the combination of HCQ and azithromycin also did not significantly impact mortality rates.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Review Virology

SARS-CoV-2: Mechanism of infection and emerging technologies for future prospects

Shiqin Li et al.

Summary: This review provided an overview of the global spread of COVID-19 caused by SARS-CoV-2, virologic and pathogenic characteristics, potential immunomodulatory mechanism, and drug development. It also proposed the application of emerging technologies in combating COVID-19 and discussed the limited epidemiology data and ongoing efforts on vaccine development.

REVIEWS IN MEDICAL VIROLOGY (2021)

Review Virology

Severe acute respiratory syndrome-coronavirus-2: Current advances in therapeutic targets and drug development

Sakthivel Suganya et al.

Summary: This review highlights the current molecular and drug advances in targeting SARS-CoV-2, including studies focusing on the genome level, host receptors, and proteases, as well as antibody-mediated therapeutic approaches and trends in vaccine development. The purpose is to investigate different molecular targets in SARS-CoV-2 pathogenesis and their usefulness in developing strategies for drug development.

REVIEWS IN MEDICAL VIROLOGY (2021)

Review Medicine, Research & Experimental

Therapeutic Measures for the Novel Coronavirus: A Review of Current Status and Future Perspective

Mahshid Shahverdi et al.

Summary: COVID-19 is a highly pathogenic and transmissible viral disease caused by SARS-CoV-2, originating in Wuhan, China. Currently, there are no clinically approved vaccines or specific antiviral drugs for COVID-19, but various therapies are being studied with a focus on effective treatment against SARS-CoV-2.

CURRENT MOLECULAR MEDICINE (2021)

Review Biotechnology & Applied Microbiology

Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story

Amin Gasmi et al.

Summary: Chloroquine and hydroxychloroquine are considered promising agents against the new coronavirus, with antiviral effects demonstrated in vitro. These drugs can reduce immune reactions, inhibit inflammation, and potentially treat viral infections and related ailments. Studies are ongoing to determine their efficacy and safety in treating COVID-19.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

Article Infectious Diseases

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

Sabeena Ahmed et al.

Summary: Ivermectin, an FDA-approved anti-parasitic agent, was found to inhibit SARS-CoV-2 replication in vitro. A trial in Bangladesh showed that a 5-day course of ivermectin can promote viral clearance in adult patients with mild COVID-19.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Article Medicine, General & Internal

The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial

Carlos Chaccour et al.

Summary: The study found that early administration of a single 400 mcg/kg dose of ivermectin did not significantly reduce the transmission of SARS-CoV-2, but it did markedly alleviate anosmia/hyposmia, reduce cough, and show a tendency to lower viral loads and IgG titers.

ECLINICALMEDICINE (2021)

Article Medical Laboratory Technology

Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia

Daniel K. W. Chu et al.

CLINICAL CHEMISTRY (2020)

Article Infectious Diseases

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M. Corman et al.

EUROSURVEILLANCE (2020)

Article Infectious Diseases

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

Chih-Cheng Lai et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Editorial Material Medicine, General & Internal

Connecting With Patients-The Missing Links

Lisa Sanders et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Letter Biochemistry & Molecular Biology

Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines

Xin Liu et al.

JOURNAL OF GENETICS AND GENOMICS (2020)

Article Virology

Potential of large first generation human-to-human transmission of 2019-nCoV

Xingguang Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Editorial Material Virology

Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle

Hongzhou Lu et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Editorial Material Microbiology

Novel coronavirus takes flight from bats?

Ashley York

NATURE REVIEWS MICROBIOLOGY (2020)

Article Medicine, General & Internal

First Case of 2019 Novel Coronavirus in the United States

Michelle L. Holshue et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Medicine, General & Internal

Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany

Camilla Rothe et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

Emmie de Wit et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Medicine, General & Internal

Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review

Junxiong Pang et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Letter Microbiology

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

Markus Hoffmann et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Article Critical Care Medicine

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

Jesus Villar et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Infectious Diseases

Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein

Naveen Vankadari

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Infectious Diseases

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

Christian A. Devaux et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Letter Medicine, General & Internal

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

Wenling Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Infectious Diseases

COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression

Dan Zhou et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Article Infectious Diseases

Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19

Zhen Zhu et al.

JOURNAL OF INFECTION (2020)

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Article Infectious Diseases

Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients

T. Klopfenstein et al.

MEDECINE ET MALADIES INFECTIEUSES (2020)

Article Public, Environmental & Occupational Health

Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility - King County, Washington, March 2020

Anne Kimball et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Article Biotechnology & Applied Microbiology

CRISPR-Cas12-based detection of SARS-CoV-2

James P. Broughton et al.

NATURE BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

A serological assay to detect SARS-CoV-2 seroconversion in humans

Fatima Amanat et al.

NATURE MEDICINE (2020)

Article Engineering, Multidisciplinary

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

Qingxian Cai et al.

ENGINEERING (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Pharmacology & Pharmacy

Structural basis of SARS-CoV-2 3CL(pro) and anti-COVID-19 drug discovery from medicinal plants

Muhammad Tahir ul Qamar et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)

Article Public, Environmental & Occupational Health

Effectiveness of Arbidol for COVID-19 Prevention in Health Professionals

Chunguang Yang et al.

FRONTIERS IN PUBLIC HEALTH (2020)

Review Microbiology

Coronavirus Disease 2019-COVID-19

Kuldeep Dhama et al.

CLINICAL MICROBIOLOGY REVIEWS (2020)

Article Pharmacology & Pharmacy

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Leon Caly et al.

ANTIVIRAL RESEARCH (2020)

Review Virology

Epidemiology and clinical features of COVID-19: A review of current literature

Juan A. Siordia

JOURNAL OF CLINICAL VIROLOGY (2020)

Article Virology

Multiplexing primer/probe sets for detection of SARS-CoV-2 by qRT-PCR

Garrett A. Perchetti et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

Review Biochemical Research Methods

CRISPR-Based Diagnosis of Infectious and Noninfectious Diseases

Somayeh Jolany Vangah et al.

BIOLOGICAL PROCEDURES ONLINE (2020)

Article Biochemistry & Molecular Biology

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

Quan-Xin Long et al.

NATURE MEDICINE (2020)

Article Nanoscience & Nanotechnology

Dexamethasone nanomedicines for COVID-19

Twan Lammers et al.

NATURE NANOTECHNOLOGY (2020)

Editorial Material Medicine, General & Internal

The Covid-19 Vaccine-Development Multiverse

Penny M. Heaton

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

David R. Boulware et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Virology

Drugs against SARS-CoV-2: What do we know about their mode of action?

Coralie Valle et al.

REVIEWS IN MEDICAL VIROLOGY (2020)

Review Virology

Emergence of novel coronavirus and progress toward treatment and vaccine

Muhammad Muzamil Khan et al.

REVIEWS IN MEDICAL VIROLOGY (2020)

Review Virology

Remdesivir: A beacon of hope from Ebola virus disease toCOVID-19

Ali Nili et al.

REVIEWS IN MEDICAL VIROLOGY (2020)

Article Infectious Diseases

Early hydroxychloroquine but not chloroquine use reduces ICU admission in COVID-19 patients

A. J. J. Lammers et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Medicine, General & Internal

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

Peter Horby et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Virology

Interleukin-6 in Covid-19: A systematic review andmeta-analysis

Eric A. Coomes et al.

REVIEWS IN MEDICAL VIROLOGY (2020)

Article Infectious Diseases

Effect of Arbidol (Umifenovir) on COVID-19: a randomized controlled trial

Marzieh Nojomi et al.

BMC INFECTIOUS DISEASES (2020)

Review Pharmacology & Pharmacy

Chloroquine, hydroxychloroquine, and COVID-19: Systematic review and narrative synthesis of efficacy and safety

Michael Takla et al.

SAUDI PHARMACEUTICAL JOURNAL (2020)

Article Rheumatology

Tocilizumab in patients with severe COVID-19: a retrospective cohort study

Giovanni Guaraldi et al.

LANCET RHEUMATOLOGY (2020)

Article Public, Environmental & Occupational Health

Epidemiologic characteristics of early cases with 2019 novel coronavirus (2019-nCoV) disease in Korea

Moran Ki

EPIDEMIOLOGY AND HEALTH (2020)

Review Virology

Coronavirus envelope protein: current knowledge

Dewald Schoeman et al.

VIROLOGY JOURNAL (2019)

Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Article Immunology

CRISPR-based rapid and ultra-sensitive diagnostic test for Mycobacterium tuberculosis

Jing-Wen Ai et al.

EMERGING MICROBES & INFECTIONS (2019)

Article Multidisciplinary Sciences

Field-deployable viral diagnostics using CRISPR-Cas13

Cameron Myhrvold et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen et al.

SCIENCE (2018)

Review Virology

RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution

Sangita Venkataraman et al.

VIRUSES-BASEL (2018)

Letter Cell Biology

CRISPR-Cas12a-assisted nucleic acid detection

Shi-Yuan Li et al.

CELL DISCOVERY (2018)

Review Immunology

Prospects for a MERS-CoV spike vaccine

Yusen Zhou et al.

EXPERT REVIEW OF VACCINES (2018)

Article Multidisciplinary Sciences

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg et al.

SCIENCE (2017)

Review Pharmacology & Pharmacy

Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases

Md Abdul Alim Al-Bari

PHARMACOLOGY RESEARCH & PERSPECTIVES (2017)

Review Immunology

Vaccines for the prevention against the threat of MERS-CoV

Lanying Du et al.

EXPERT REVIEW OF VACCINES (2016)

Article Multidisciplinary Sciences

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren et al.

NATURE (2016)

Review Biotechnology & Applied Microbiology

Coronaviruses - drug discovery and therapeutic options

Alimuddin Zumla et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Review Biochemistry & Molecular Biology

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

Shuo Su et al.

TRENDS IN MICROBIOLOGY (2016)

Article Multidisciplinary Sciences

Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import

Veronika Goetz et al.

SCIENTIFIC REPORTS (2016)

Article Health Care Sciences & Services

Lopinavir/ritonavir in the treatment of HIV-1 infection: a review

Jonathan Shuter

Therapeutics and Clinical Risk Management (2016)

Article Pharmacology & Pharmacy

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

Lisa Oestereich et al.

ANTIVIRAL RESEARCH (2014)

Review Pharmacology & Pharmacy

Arbidol as a broad-spectrum antiviral: An update

Julie Blaising et al.

ANTIVIRAL RESEARCH (2014)

Review Pharmacology & Pharmacy

The SARS coronavirus nucleocapsid protein - Forms and functions

Chung-ke Chang et al.

ANTIVIRAL RESEARCH (2014)

Article Biology

CORONAVIRUS GENOMICS AND BIOINFORMATICS ANALYSIS

Patrick C. Y. Woo et al.

OMICS IN CLINICAL PRACTICE: GENOMICS, PHARMACOGENOMICS, PROTEOMICS, AND TRANSCRIPTOMICS IN CLINICAL RESEARCH (2014)

Review Virology

The Coronavirus Nucleocapsid Is a Multifunctional Protein

Ruth McBride et al.

VIRUSES-BASEL (2014)

Review Pharmacology & Pharmacy

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

Yousuke Furuta et al.

ANTIVIRAL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Changes in the major cell envelope components of Mycobacterium tuberculosis during in vitro growth

Lanhao Yang et al.

GLYCOBIOLOGY (2013)

Article Infectious Diseases

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

Jasper F. W. Chan et al.

JOURNAL OF INFECTION (2013)

Article Multidisciplinary Sciences

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

Peter B. Madrid et al.

PLOS ONE (2013)

Review Biochemistry & Molecular Biology

Interspecies transmission and emergence of novel viruses: lessons from bats and birds

Jasper Fuk-Woo Chan et al.

TRENDS IN MICROBIOLOGY (2013)

Article Biochemistry & Molecular Biology

Favipiravir (T-705) inhibits in vitro norovirus replication

J. Rocha-Pereira et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Immunology

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

Alenka Kuznik et al.

JOURNAL OF IMMUNOLOGY (2011)

Review Virology

Coronavirus Genomics and Bioinformatics Analysis

Patrick C. Y. Woo et al.

VIRUSES-BASEL (2010)

Review Cell Biology

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Paul Saftig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

Rowena E. Martin et al.

SCIENCE (2009)

Review Pharmacology & Pharmacy

The pharmacokinetics and interactions of ivermectin in humans - A mini-review

Aranzazu Gonzalez Canga et al.

AAPS JOURNAL (2008)

Article Infectious Diseases

The SARS-CoV nucleocapsid protein: A protein with multifarious activities

Milan Surjit et al.

INFECTION GENETICS AND EVOLUTION (2008)

Review Chemistry, Medicinal

Lysosomal sequestration of amine-containing drugs: Analysis and therapeutic implications

Allyn M. Kaufmann et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2007)

Article Multidisciplinary Sciences

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

G Simmons et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines

B Morgenstern et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Virology

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Martin J. Vincent et al.

VIROLOGY JOURNAL (2005)

Article Biochemistry & Molecular Biology

In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

E Keyaerts et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Letter Medical Laboratory Technology

Rapid diagnosis of a coronavirus associated with severe acute respiratory syndrome (SARS)

LLM Poon et al.

CLINICAL CHEMISTRY (2003)

Article Medicine, General & Internal

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

C Drosten et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Review Biochemistry & Molecular Biology

A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

JA Bruenn

NUCLEIC ACIDS RESEARCH (2003)

Article Virology

Early diagnosis of SARS Coronavirus infection by real time RT-PCR

LLM Poon et al.

JOURNAL OF CLINICAL VIROLOGY (2003)

Review Biochemistry & Molecular Biology

Real-time PCR in virology

IM Mackay et al.

NUCLEIC ACIDS RESEARCH (2002)

Article Biochemical Research Methods

Development of a fluorogenic RT-PCR assay (TaqMan) for the detection of Hendra virus

IL Smith et al.

JOURNAL OF VIROLOGICAL METHODS (2001)